Abstract
Mantle cell lymphoma (MCL) is an aggressive B-cell neoplasm with cutaneous involvement in ∼1% of cases. We present a single institutional series of nine patients (12 specimens) with cutaneous involvement by systemic MCL and review the clinicopathologic features. Six males and 3 females (age range 55-87 years) were included. Sites of involvement were head and neck (n = 3), trunk (n = 5), and extremities (n = 4). Histopathologically, 3 showed classic cytomorphology, 2 were blastoid, 3 pleomorphic, and 1 showed features resembling marginal zone lymphoma. Two cases presented with cutaneous lesions as the first tissue manifestation of the disease. A second malignancy was identified in 3/9 cases (2 melanomas and 1 papillary thyroid carcinoma). In one patient, MCL was juxtaposed with metastatic melanoma within the same biopsy specimen. Fluorescence in situ hybridization studies, when available, demonstrated the characteristic t(11,14) translocation. Direct immunofluorescence was performed on one case and showed immunoglobulin M (IgM) expression on the tumor cells. Follow-up was available in 7 cases (mean 42 months, range 6-78 months) and revealed death from disease for 6 patients that occurred within 1 week to 11 months (mean 4 months...Continue Reading
References
Nov 15, 2000·The American Journal of Surgical Pathology·P LinL J Medeiros
Nov 17, 2001·Journal of the American Academy of Dermatology·L F LibowG T Bessinger
Feb 21, 2002·Surgery·Shawn D St PeterBarbara A Pockaj
Oct 3, 2002·The American Journal of Surgical Pathology·Filiz SenLynne V Abruzzo
Jan 12, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M B Lens, J A Newton-Bishop
Jun 25, 2005·Archives of Pathology & Laboratory Medicine·Erica JacobsonBarbara H Tindle
Feb 24, 2007·Human Pathology·Adnan MansoorRaymond Lai
May 23, 2009·The American Journal of Dermatopathology·Bruna EstroziCarlos E Bacchi
Mar 18, 2010·Acta Haematologica·Juanah AddadaEstella Matutes
Jun 17, 2010·The American Journal of Surgical Pathology·Lianne KoensPatty M Jansen
Nov 30, 2011·Journal of Cutaneous Pathology·Douglas W LynchAli D Jassim
Jan 19, 2012·The American Journal of Surgical Pathology·Weifen ZengEric D Hsi
Dec 28, 2012·Journal of Clinical and Experimental Hematopathology : JCEH·Yoshinori HashimotoShu Nakamoto
Apr 25, 2013·The American Journal of Dermatopathology·Anna Maria CesinaroMarina Milani
Nov 22, 2013·JAMA Dermatology·Sarah I JawedChristiane Querfeld
Mar 1, 2011·Journal of Hematopathology·Ulla RandenJan Delabie
Jun 3, 2015·The American Journal of Surgical Pathology·Ulrike WehkampIlske Oschlies
Jan 15, 2016·Journal of Cutaneous Pathology·Andy C HsiAndrás Schaffer
Apr 29, 2016·Molecular and Clinical Oncology·Igor HrgovicMarkus Meissner
Aug 20, 2016·Journal of Cutaneous Pathology·Alejandro A GruJohn L Frater
Jun 21, 2019·The American Journal of Surgical Pathology·Do Hwan KimChi Young Ok
Oct 28, 2019·Proceedings·Madhuri BadrinathAdham Jurdi
Apr 27, 2020·Journal of Cutaneous Pathology·Andrew N MinzenmayerPalak K Parekh