Cutaneous lipoma in children: 5 cases with Bannayan-Riley-Ruvalcaba syndrome

Journal of Pediatric Surgery
Philippe BuissonYves Heloury

Abstract

Cutaneous lipoma is rare in children, but it can be part of a syndrome such as the Bannayan-Riley-Ruvalcaba syndrome (BRRS). The BRRS is a dominant autosomal disorder characterized by cutaneous lipomas, macrocephaly, intestinal polyps, and developmental delay associated with PTEN gene mutations. This syndrome is thought to represent a pediatric form of the Cowden syndrome, characterized among other features by an increased risk of cancer. We report 5 cases of BRRS, all diagnosed in children with lipoma and macrocephaly. Children presenting with lipomas need a complete physical examination to look for other signs of BRRS, because they may need further follow-up for tumor screening in adulthood.

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Citations

Oct 19, 2013·Journal of the National Cancer Institute·Robert PilarskiElizabeth Swisher
Jul 11, 2009·Plastic and Reconstructive Surgery·Wai-Yee Li, John F Reinisch
Jan 17, 2012·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·A VerloesUNKNOWN Réseau DéfiScience
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Aug 1, 2015·International Journal of Dermatology·Mehdi IskandarliAsli Aslan
Apr 13, 2017·Pediatric Gastroenterology, Hepatology & Nutrition·Sun Hwa LeeHann Tchah
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Jul 14, 2020·Pediatric Dermatology·Hélène MartinUNKNOWN Groupe de Recherche de la Société Française de Dermatologie Pédiatrique
Jun 21, 2019·Cancers·Robert Pilarski

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