Cutaneous localization of endothelin-1 in patients with systemic sclerosis: immunoelectron microscopic study

International Journal of Dermatology
H TabataS Yamazaki

Abstract

Endothelin-1 (ET-1) has some relation to the pathogenesis of systemic sclerosis (SSc) and Raynaud's phenomenon. This study was performed to determine the localization of ET-1 in patients with SSc. The localization of ET-1 on the specimen by skin biopsies from nine patients with SSc, was observed with immunoelectron microscopic techniques. High-density deposits existed on the ribosomes and on the rough endoplasmic reticulum in the endothelial cells of microvessels of the upper dermis. The same findings were also seen in the fibroblasts of the dermis, but not found in the skin of normal controls. The level of deposits in the endothelial cells and dermal fibroblasts seemed to have a positive correlation with the serum levels of ET-1 of patients with SSc. From these results, it can be seen that ET-1 is produced much more from the endothelial cells and fibroblasts of the dermis in the skin of SSc patients than from the normal controls. It is suspected that ET-1 is one of the pathogenetic factors of SSc.

Citations

Aug 17, 2000·Springer Seminars in Immunopathology·A JelaskaJ H Korn
Feb 11, 2005·Journal of Molecular Histology·Andrzej LoeschAntonio A C M Ribeiro
Dec 11, 2008·Clinical Reviews in Allergy & Immunology·Fredrick M Wigley
Feb 13, 2001·International Journal of Dermatology·H TabataN Koibuchi
Nov 12, 2010·Annals of the Rheumatic Diseases·Giuseppina FarinaRobert Lafyatis
May 25, 2002·Journal of Cutaneous Pathology·Robert HarfordHenry Skelton
Jul 5, 2003·Rheumatic Diseases Clinics of North America·Filemon K Tan
May 4, 2005·The International Journal of Lower Extremity Wounds·Arun Chakrabarty, Tania Phillips
Sep 6, 2014·Current Opinion in Rheumatology·Nezam AltorokBashar Kahaleh
Mar 30, 2000·Autoimmunity·M B Kahaleh, E C LeRoy
Mar 25, 1998·Seminars in Cutaneous Medicine and Surgery·B Liu, M K Connolly

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