Cutaneous manifestations of angioimmunoblastic T-cell lymphoma: clinical and pathological characteristics

The American Journal of Dermatopathology
Noha BotrosNoreen M Walsh

Abstract

Angioimmunoblastic T-cell lymphoma (AITL), an uncommon variant of peripheral T-cell lymphoma, affects the skin in approximately 50% of cases. Its protean clinical and histopathological cutaneous manifestations pose a challenge in diagnosis, particularly when these precede the diagnosis of AITL on a lymph node biopsy. In this retrospective study, we compared 11 cases of AITL with cutaneous manifestations (mean age 67 years; male:female ratio 1:0.8; 24 skin biopsies) with 20 control cases of inflammatory and non-AITL lymphomatous diseases (mean age 52 years; male:female ratio 1:1.5; 26 skin biopsies). Clinical, histopathological, immunohistochemical, and molecular data were documented. New insights into the clinical evolution of cutaneous involvement by AITL (C-AITL), from early macular, through papular to nodular stages, were observed. Microscopically, a parallel increment in the density of the dermal infiltrate and in the detection of lymphocyte cytological atypia was noted over time. Identification and quantification of follicular T-helper cells (Tfh), the neoplastic lineage, by immunohistochemistry helped to separate cases of C-AITL from inflammatory controls, offering promise as a useful diagnostic adjunct. The presence of T...Continue Reading

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Citations

Dec 17, 2016·Seminars in Diagnostic Pathology·Lorenzo Cerroni
Mar 28, 2017·Hematology/oncology Clinics of North America·Alessandro Broccoli, Pier Luigi Zinzani
Jul 5, 2017·Journal of Cutaneous Pathology·Shamir GellerPatricia L Myskowski
Sep 26, 2017·The American Journal of Surgical Pathology·Ariane Leclaire AlirkilicarslanNicolas Ortonne
Aug 19, 2015·Journal of Cutaneous Pathology·Carlos SantonjaSocorro María Rodríguez-Pinilla
Feb 18, 2020·Proceedings·Rahul SawhneyBarry Cooper
Sep 3, 2020·World Journal of Clinical Oncology·Teiko KawahigashiEri Tanaka
Dec 10, 2020·JAAD Case Reports·Taylor C DukeMeghan Heberton
Jun 22, 2020·Hematology, Transfusion and Cell Therapy·Beenish IqbalTanzeem Haider Raza
Oct 17, 2021·Journal of Cutaneous Pathology·Lauren G YiShyam S Raghavan

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