Cutaneous manifestations of patients with relapsing polychondritis: an association with extracutaneous complications

Clinical Rheumatology
Jun ShimizuNoboru Suzuki

Abstract

The aim of this study was to determine the prognostic characteristics of patients with relapsing polychondritis (RP) accompanying cutaneous manifestations in Japan. We analyzed a cohort of 239 patients with RP in view of cutaneous and extracutaneous complications. Thirty three cases (14%) developed cutaneous manifestations and 23 cases had both cutaneous and extracutaneous manifestations. Five RP patients developed myelodysplastic syndrome (MDS) and all of the five patients had cutaneous manifestations, including Sweet's syndrome. Only one patient died of MDS among the five patients, suggesting rather better prognosis as compared with ordinary MDS. Five RP patients developed Behcet's disease and all the five patients had cutaneous manifestations. Death rate of the RP patients with cutaneous manifestations (15%) was slightly higher than that of whole Japanese RP patient cohort (9.2%). RP patients with cutaneous manifestations had a slightly higher death rate, than those without cutaneous manifestations. MDS of RP patients had a rather better prognostic impact in Japan. Further studies are needed to elucidate the pathophysiology of RP, which brings about development of extracutaneous manifestations, especially MDS and Behcet's di...Continue Reading

References

Feb 1, 1997·Leukemia & Lymphoma·H Enright, W Miller
Jun 22, 2002·Seminars in Arthritis and Rheumatism·Erik LetkoC Stephen Foster
Sep 30, 2004·Best Practice & Research. Clinical Rheumatology·Peter Gergely, Gyula Poór
Dec 12, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·M DalamagaE Papadavid
Apr 2, 2009·International Journal of Dermatology·Shannon WatkinsFrancisco A Ramos-Caro
Sep 13, 2015·Rheumatology·Jun ShimizuNoboru Suzuki

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Citations

Feb 16, 2016·Autoimmunity Reviews·Lucia LongoMarco De Vincentiis
Oct 4, 2016·American Journal of Clinical Dermatology·AnneLiese SmylieAlain Brassard
Oct 11, 2017·International Journal of Dermatology·Daniel CuestasOscar Velasquez
Oct 27, 2017·Medicine·Anna MydlakKrzysztof Mucha
Sep 14, 2018·Journal of Immunology Research·Massimo RalliMarco de Vincentiis
Aug 6, 2021·Laryngo- rhino- otologie·Stephan HackenbergAgmal Scherzad

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