Cutaneous metastasis from anaplastic thyroid carcinoma exhibiting exclusively a spindle cell morphology. A case report and review of literature

Journal of Cutaneous Pathology
Richard DanialanJonathan L Curry

Abstract

Anaplastic thyroid carcinoma is a highly aggressive cancer accounting for 1-2% of thyroid malignancies. Cutaneous metastases from anaplastic thyroid carcinoma are exceedingly rare. We report a 65-year-old woman with anaplastic thyroid carcinoma (BRAF V600E mutation) who had lymph node metastases (pT4 N1b) treated by total thyroidectomy, postoperative radiotherapy, adjuvant chemotherapy (paclitaxel and pazopanib) and targeted therapy (vemurafenib). Nine months after initial diagnosis, radiographic studies revealed multiple pulmonary metastases. A dermatologic examination showed a solitary 1.2-cm chest nodule. Skin biopsy from this nodule revealed infiltrative dermal spindle cells arranged in poorly formed fascicles. Immunohistochemical studies demonstrated the tumor cells to be PAX-8 (+), pancytokeratin (+, focally), TTF-1 (-) and SOX-10 (-). Comparison with the patient's primary anaplastic thyroid carcinoma revealed focal areas of poorly differentiated spindle cells morphologically similar to the malignant spindle cells in the skin biopsy. Together, these findings confirmed the diagnosis of anaplastic thyroid carcinoma metastatic to skin. Cutaneous metastasis of anaplastic thyroid carcinoma composed exclusively of spindle cells...Continue Reading

References

Apr 1, 1992·American Journal of Clinical Pathology·C K MaA M Gown
Jul 1, 1991·American Journal of Clinical Pathology·N G OrdóñezN A Samaan
Jan 1, 1974·Journal of Cutaneous Pathology·R Barr, F Dann
Aug 1, 1996·International Journal of Dermatology·S TaniguchiT Hamada
Dec 1, 1996·The American Journal of Surgical Pathology·T A LongacreR V Rouse
Apr 1, 1997·Journal of the American Academy of Dermatology·P R DahlI D Hay
Sep 23, 1997·The American Journal of Surgical Pathology·S KadduH P Soyer
Apr 17, 2002·Virchows Archiv : an International Journal of Pathology·A SakamotoM Tsuneyoshi
Jun 17, 2006·Journal of Cutaneous Pathology·Jorge E Dotto, Earl J Glusac
Dec 18, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Daisuke NonakaRonald Ghossein
May 23, 2008·The American Journal of Dermatopathology·Michael B MorganTiffany R Anglin
Jul 19, 2008·The American Journal of Surgical Pathology·Daisuke NonakaBrian P Rubin
Jun 11, 2009·Thyroid : Official Journal of the American Thyroid Association·Rajan S PatelJudith M Balogh
Dec 24, 2010·The Korean Journal of Internal Medicine·Kyu-Hyoung LimJong Seok Lee
Feb 3, 2011·Applied Immunohistochemistry & Molecular Morphology : AIMM·David TachaLiang Cheng
Feb 15, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ayhan OzcanLuan D Truong
Sep 3, 2011·Journal of Cutaneous Pathology·Carilyn N WielandNneka I Comfere
Apr 13, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Jason R KaramchandaniRobert B West
Jan 8, 2013·The American Journal of Dermatopathology·Beth PallaSarah Dry
Jun 17, 2014·Oncology Letters·Serdar AltinayPelin Altinok Süt
Jul 17, 2014·The American Journal of Surgical Pathology·Samuel A HendersonMichael T Tetzlaff
Sep 30, 2014·Journal of Cutaneous Pathology·Ahmed K AlomariJennifer M McNiff

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.