Cutaneous metastasis of a radiation-associated thyroid medullary carcinoma

Journal of Endocrinological Investigation
G BevilacquaE Martino

Abstract

The rare event of a single cutaneous metastasis occurred in a 37-year-old white man two years after a subtotal thyroidectomy for sporadic medullary carcinoma is reported. The endocrine nature of the tumor is revealed by the ultrastructural study, and the type of secretion by the biochemical assay of calcitonin (CT) in the serum and in the tumor tissue extract and by the PAP (peroxidase-anti-peroxidase) technique with anti-CT antibodies on paraffin sections. The cytological and histological findings are described. Some peculiar ultrastructural aspects are presented in details. The fact that the patient received a course of Rx therapy (3,000 rads) on the neck for cervical syringomyelia at the age of 20 years is stressed.

References

Jan 23, 1975·The New England Journal of Medicine·S RefetoffC Bekerman
Dec 1, 1977·The American Journal of Medicine·H R MaxonJ G Kereiakes
Feb 1, 1978·The American Journal of Medicine·A B SchneiderL A Frohman
Jan 1, 1982·Acta Endocrinologica·V Thurston, E D Williams

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Citations

Jul 25, 2008·Thyroid : Official Journal of the American Thyroid Association·Libero SantarpiaNicholas J Sarlis
Sep 3, 2011·The American Journal of Dermatopathology·Sanaz Sanii, Seyed Mohammad Tavangar
Jul 21, 2009·Journal of Cutaneous Pathology·Catherine NashedRonald Scott Chamberlain
Nov 20, 2009·Journal of Cutaneous Pathology·Mahmoud Rezk Abdelwahed Hussein

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