PMID: 8599476Dec 1, 1995Paper

Cutaneous metastasis of CNS chordoma

The American Journal of Dermatopathology
H OgiM Fukui

Abstract

A rare case of cutaneous skin metastasis from an intracranial chordoma is presented. A large nodule developed in the left thigh of a 22-year-old woman who had been previously diagnosed to have a chordoma at the base of her skull. Sections from the biopsied specimens of the nodule showed proliferations of physaliphorous cells and stellate cells in cords and in nests in a myxoid stroma. Immunohistochemically, neoplastic cells were stained positively with antibodies to S-100 protein and cytokeratin. The results of the histopathological and immunohistochemical studies of the nodule were interpreted as pointing to a diagnosis of metastatic chordoma based on their similarity to the results of studies of the primary neoplasm in the cranial region. Based on the number of cases of skin metastasis from chordoma reported in the literature, skin should be kept in mind as one of the target organs, although such metastases are still rare.

Citations

Jan 7, 2010·The American Journal of Dermatopathology·Angel Fernandez-Flores
Dec 14, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Greg PersichettiRoger I Ceilley
Nov 20, 2009·Journal of Cutaneous Pathology·Mahmoud Rezk Abdelwahed Hussein
Jul 18, 2006·Journal of the American Academy of Dermatology·Nektarios I LountzisJacqueline M Junkins-Hopkins
Dec 5, 2002·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·F MeneghiniU Zanetti
Apr 29, 2005·Journal of the American Academy of Dermatology·Adam I RubinGeorge Niedt
Oct 19, 2016·The American Journal of Dermatopathology·Kristyna GleghornRamon Sanchez
Feb 1, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Cynthia M MagroMartin C Mihm
Jul 24, 2002·Journal of Cutaneous Pathology·A Neil CrowsonTamara Hill
Jul 20, 2005·Australasian Radiology·F M MacleanT Ng
Jul 14, 2011·British Journal of Neurosurgery·Brian J JianAndrew T Parsa
Apr 12, 2000·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·H A RuizJ B Blacklock

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