PMID: 2504625Jan 1, 1989Paper

Cutaneous necrosis associated with the lupus anticoagulant

Dermatologica
Camille FrancèsP Godeau

Abstract

Extensive cutaneous necrosis of the limbs with sudden onset was observed in 3 women suffering from benign systemic lupus erythematosus. All 3 had a circulating anticoagulant and a positive venereal diseases reference laboratory test without anticardiolipin antibodies. They were successfully treated with pulse methylprednisolone therapy and plasmapheresis. The necrosis-lupus anticoagulant relationship is discussed due to the absence of another possible etiology for cutaneous necrosis and the latter's histological aspect, i.e., thromboses of the dermal and hypodermal vessels without vasculitis. This cutaneous necrosis resembles that observed in congenital protein C deficiencies and favors the hypothesis of interaction between the lupus anticoagulant and the protein C-S complex.

Citations

Jul 1, 1996·Clinical Rheumatology·I M JouS C Chao
Jan 1, 1995·Clinical Reviews in Allergy & Immunology·J C PietteB Wechsler
Apr 1, 1997·Clinical Reviews in Allergy & Immunology·I DeclevaE Berti
Feb 1, 1997·Journal of the American Academy of Dermatology·G T Nahass
Oct 17, 2006·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·José RossiniSergio Paira
May 8, 1999·The British Journal of Dermatology·O IshikawaY Miyachi
Dec 3, 1999·The British Journal of Dermatology·A V MarzanoR Caputo
Sep 25, 1998·The British Journal of Dermatology·J T LearP E Hutchinson
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Dec 21, 2006·Clinical and Experimental Dermatology·F A WandrooB Sinha
Jun 4, 2005·Arthritis and Rheumatism·Camille FrancèsJean Charles Piette
Nov 5, 2003·Annals of Plastic Surgery·Lisa M DiFrancescoJames G Hoehn
Jun 1, 1997·Journal of the American Academy of Dermatology·G E GibsonM R Pittelkow

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