PMID: 6127365Nov 1, 1982Paper

Cutaneous neuropathology in multiple endocrine neoplasia, type 2b

The Journal of Investigative Dermatology
R K Winkelmann, J A Carney


Increase in masses of mixed (myelinated and nonmyelinated) nerve are observed in the dermis of clinically normal skin of patients with multiple endocrine neoplasia, type 2b (MEN 2b). Preliminary histochemical studies revealed nucleoside triphosphatase and nonspecific acid esterase. Electron microscopy showed axonal organelles, mild degeneration of axons, and numerous axons unassociated with Schwann cells. The normal-appearing skin in MEN 2b seems to contain abnormal nerve tissue development equally with the mucosal and the gastrointestinal tract.


Dec 12, 2001·The British Journal of Dermatology·F TruchotH Perrot
Aug 23, 2012·Journal of Cutaneous Pathology·Maxwell A Fung
Jun 13, 2018·The American Journal of Dermatopathology·Alejandro Lobato-BerezoMaría Teresa Fernández-Figueras
May 27, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Andrea Saggini, Maria Luisa Brandi
Jan 5, 2017·Clinical and Experimental Dermatology·N WatsonA MacDonald
Jun 23, 2009·The American Journal of Dermatopathology·Ayman Al HabeebDanny Ghazarian
Jun 20, 2017·Journal of Cutaneous Pathology·Stephanie J T ChenDouglas R Fullen

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