Cutaneous papillomatosis and carcinomatosis in the Western barred bandicoot (Perameles bougainville)

Veterinary Pathology
Lucy WoolfordKristin S Warren

Abstract

A progressive wart-like syndrome in both captive and wild populations of the Western barred bandicoot (WBB) is hindering conservation efforts to prevent the extinction of this endangered marsupial. In this study, 42 WBBs exhibiting the papillomatosis and carcinomatosis syndrome were examined. The disease was characterized by multicentric proliferative lesions involving cutaneous and mucosal surfaces, which were seen clinically to increase in size with time. Grossly and histologically the smaller skin lesions resembled papillomas, whereas the larger lesions were most commonly observed to be squamous cell carcinomas. Large amphophilic intranuclear inclusion bodies were observed in hyperplastic conjunctival lesions of 8 WBBs under light microscopy. Conjunctival lesions from 2 WBBs examined using transmission electron microscopy contained a crystalline array of spherical electron-dense particles of 45-nm diameter, within the nucleus of conjunctival epithelial cells, consistent with a papillomavirus or polyomavirus. Conjunctival samples from 3 bandicoots that contained intranuclear inclusion bodies also demonstrated a positive immunohistochemical reaction after indirect immunohistochemistry for papillomavirus structural antigens. Ul...Continue Reading

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Citations

Oct 24, 2014·Proceedings. Biological Sciences·Helen M BrowningJohn A Hammond
Jun 10, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Paul W Ewald, Holly A Swain Ewald
Jun 28, 2016·Veterinary Dermatology·Evie C KnightMichael A Shipstone
Jul 29, 2016·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Maria ArdiacaMario Soriano-Navarro
Jan 29, 2010·Veterinary Pathology·J S Munday, M Kiupel
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Aug 18, 2018·Nature Reviews. Cancer·Patricia A PesaventoKevin D Woolard
Aug 22, 2020·Evolutionary Applications·Rodrigo HamedeFrédéric Thomas

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Methods Mentioned

BETA
biopsies
transmission electron microscopy
light microscopy
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