Cutaneous Papillomaviruses and Non-melanoma Skin Cancer: Causal Agents or Innocent Bystanders?

Frontiers in Microbiology
Daniel HascheFrank Rösl

Abstract

There is still controversy in the scientific field about whether certain types of cutaneous human papillomaviruses (HPVs) are causally involved in the development of non-melanoma skin cancer (NMSC). Deciphering the etiological role of cutaneous HPVs requires - besides tissue culture systems - appropriate preclinical models to match the obtained results with clinical data from affected patients. Clear scientific evidence about the etiology and underlying mechanisms involved in NMSC development is fundamental to provide reasonable arguments for public health institutions to classify at least certain cutaneous HPVs as group 1 carcinogens. This in turn would have implications on fundraising institutions and health care decision makers to force - similarly as for anogenital cancer - the implementation of a broad vaccination program against "high-risk" cutaneous HPVs to prevent NMSC as the most frequent cancer worldwide. Precise knowledge of the multi-step progression from normal cells to cancer is a prerequisite to understand the functional and clinical impact of cofactors that affect the individual outcome and the personalized treatment of a disease. This overview summarizes not only recent arguments that favor the acceptance of a ...Continue Reading

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Citations

Apr 9, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Assunta VenutiSigrun Smola
Jul 11, 2019·Virus Genes·Evelyn OswaldEeva Auvinen
Feb 24, 2019·Viruses·Daniel Hasche, Frank Rösl
Nov 30, 2019·Pathogens·Jazmine A SnowNicholas A Wallace
Nov 8, 2020·Animals : an Open Access Journal From MDPI·Marta PolinasElisabetta Antuofermo
Dec 18, 2020·Nature·Paul F LambertMassimo Tommasino
Mar 3, 2021·Journal of Cellular and Molecular Medicine·Kristijan SkokRajko Kavalar
Mar 30, 2021·Clinical Kidney Journal·Steven Van Laecke, Wim Van Biesen
Dec 2, 2021·Journal of the National Cancer Institute·Daniel DiMaioAmy Justice

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Methods Mentioned

BETA
whole-genome shotgun sequencing
transgenic
acetylation
lipidation

Software Mentioned

PaVE
PREVENT

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