PMID: 12671586Apr 3, 2003

Cutaneous polyarteritis nodosa following hepatitis B vaccination

Annales de dermatologie et de vénéréologie
A-M BourgeaisJ-L Verret

Abstract

We report the original case of cutaneous periarteritis nodosa that occurred one month following vaccination against hepatitis B. A 37 year-old woman, without notable past history, taking no medication, presented with a livedo that had appeared one month after the first injection of a hepatitis B vaccination and had slowly extended over the past 7 years. She did not complain of any other symptom. The histological examination of the livedo showed a necrotic vasculitis. The clinical picture, the histological image and the slow 7-year progression led to the diagnosis of cutaneous periarteritis nodosa. Treatment with hydroxychloroquine (Plaquenil) followed by colchicine had no effect on the livedo. Cutaneous periarteritis nodosa is a rare disease of unknown physiopathology. It can be distinguished from systemic periarteritis nodosa by the absence of systemic involvement and benign but prolonged progression. The association of systemic periarteritis nodosa and hepatitis B has been demonstrated. Conversely, only one case of cutaneous periarteritis nodosa associated with hepatitis B viral infection has been described. The vaccination against hepatitis B is frequently prescribed. Following vaccination, a few cases of vasculitis have bee...Continue Reading

Related Concepts

Polyarteritis Nodosa
Dermatologic Disorders
Hepatitis B Vaccines

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