Cutaneous pseudovasculitis, antiphospholipid syndrome and obstetric misadventure

Lupus
A S Thayaparan, S A Lowe

Abstract

We present two women with severe obstetric complications from antiphospholipid (aPL) syndrome associated with a rare dermatological manifestation, cutaneous pseudovasculitis. Both of these women developed a rash on the palmar aspect of the hands during the post partum period, with histology consistent with microthrombotic disease, despite anticoagulation. Cutaneous pseudovasculitis appears to be a maternal manifestation of aPL coagulopathy, possibly reflecting the severity of the underlying pregnancy pathology.

References

Apr 16, 2002·Arthritis and Rheumatism·Ricard CerveraUNKNOWN Euro-Phospholipid Project Group
Jun 4, 2005·Arthritis and Rheumatism·Camille FrancèsJean Charles Piette
Feb 8, 2007·The American Journal of Dermatopathology·J Andrew Carlson, Ko-Ron Chen
Nov 13, 2007·American Journal of Obstetrics and Gynecology·Anne Flem JacobsenPer Morten Sandset

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Citations

Oct 31, 2018·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Rosanna Satta, Gabriele Biondi
Jan 26, 2021·Case Reports in Obstetrics and Gynecology·Rie NakajimaHitoshi Ishimoto

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Methods Mentioned

BETA
biopsy

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Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

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