PMID: 7544812Sep 1, 1995Paper

Cutaneous reactions to recombinant cytokine therapy

Journal of the American Academy of Dermatology
L A Asnis, A A Gaspari

Abstract

Cytokines are critical to several fundamental homeostatic mechanisms such as fever, acute phase reactions, wound healing, hematopoiesis, inflammation, cellular and humoral immune responses, and tumor regression. As a result of advances in recombinant DNA technology, recombinant cytokines are available as therapeutic agents. They have been used for metastatic cancers and immunodeficiencies, as a therapy for naturally occurring or drug-induced anemias or leukopenias, and they have also been applied to some cutaneous disorders. Cytokine therapy can result in toxic reactions that affect many organ systems, especially the skin. These reactions are common and diverse, ranging from minor injection site reactions, pruritus, and flushing to life-threatening autoimmune disorders, severe erythroderma, or bullous skin reactions. This review focuses on the major cytokines that are in current clinical use or under investigation and describes the cutaneous complications of these agents.

References

Jun 15, 1992·Annals of Internal Medicine·J W ParkA P Venook
Jun 20, 1992·BMJ : British Medical Journal·T Perren, P Selby
Aug 1, 1992·The British Journal of Dermatology·L S OstlereM H Rustin
Sep 1, 1992·Research in Immunology·J J MuléS A Rosenberg
Dec 1, 1992·Toxicology Letters·J B CornacoffJ H Dean
Aug 1, 1992·Archives of Dermatology·D R MehreganK M Leiferman
Jul 1, 1992·Journal of Clinical Immunology·M HowardJ de Vries
Jun 11, 1992·Southern Medical Journal·J S WienerP J Walther
Mar 1, 1992·The Journal of Pediatrics·A TolaymatC Monteiro
Apr 1, 1992·Archives of Dermatology·S J Orlow, A E Friedman-Kien
Oct 1, 1991·Journal of the American Academy of Dermatology·P R Cohen, R Kurzrock
Jan 15, 1992·Cancer·J M RichardsN J Vogelzang
Sep 1, 1991·Contact Dermatitis·P D PigattoA Riboldi
Jun 1, 1991·Journal of the American Academy of Dermatology·T A Luger, T Schwarz
Nov 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M J KleinerA Sollazzo
Jan 2, 1991·Journal of the National Cancer Institute·M R StauntonF R Aronson
Jun 20, 1990·Journal of the National Cancer Institute·F L MeyskensC Coltman
Oct 1, 1990·Contact Dermatitis·A Scheynius, C Skoglund
Jan 1, 1990·Annual Review of Immunology·J Van Snick
Jan 15, 1990·Annals of Internal Medicine·D R SnydmanM B Atkins
Feb 15, 1989·Annals of Internal Medicine·R H WeisbartD W Golde
Jul 1, 1989·Annals of Internal Medicine·R DreicerP P Carbone
Jul 1, 1989·Annals of Internal Medicine·L H Calabrese
Jul 1, 1989·Annals of Internal Medicine·B DrenoW Y Godefroy
Oct 15, 1989·Annals of Internal Medicine·P A RobertsonR A Figlin
Jun 28, 1986·Lancet·J R Quesada, J U Gutterman
Dec 1, 1988·Archives of Dermatology·R E LeeS A Rosenberg
Sep 25, 1987·JAMA : the Journal of the American Medical Association·A A GaspariS I Katz
Dec 4, 1987·JAMA : the Journal of the American Medical Association·A WeinsteinM Davidian
Mar 1, 1982·The Journal of Experimental Medicine·M HowardW E Paul

❮ Previous
Next ❯

Citations

Dec 13, 2005·Pharmacy World & Science : PWS·Stefan SleijferGerrit Stoter
Nov 1, 1996·Journal of the American Academy of Dermatology·A TranvanK M Soltani
Mar 1, 1997·Matrix Biology : Journal of the International Society for Matrix Biology·K TiedemannG Westergren-Thorsson
Aug 1, 1997·Seminars in Veterinary Medicine and Surgery (small Animal)·K R Van Kampen
Sep 21, 2001·Drug Discovery Today·S G. Miller
Sep 6, 2000·Clinical and Experimental Dermatology·A M Downs, M G Dunnill
Sep 24, 1999·Acta Dermato-venereologica·A Herrera Saval, F Camacho Martínez
Apr 1, 1997·The British Journal of Dermatology·M J CorkS S Bleehen
May 18, 2011·Pediatric Dermatology·Michelle FoxCaroline C Kim
Dec 18, 2004·Dermatology : International Journal for Clinical and Investigative Dermatology·M HofmannU Trefzer
Jul 28, 2007·Orphanet Journal of Rare Diseases·Philip R Cohen
May 23, 2007·Clinical Drug Investigation·Sebastiano ScavoSergio Neri
Aug 22, 2006·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·David J KoubaAnthony A Gaspari
Oct 2, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Brian A Baldo
Dec 23, 1995·Lancet·J D Bernhard
Mar 5, 1998·Journal of the American Academy of Dermatology·A A Gaspari, A Zalka
Apr 27, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Peter W HendersonJason A Spector
Oct 3, 2003·International Journal of Dermatology·Philip R Cohen, Razelle Kurzrock
Mar 26, 2003·Histopathology·M R Canninga-van DijkJ G van den Tweel
Mar 9, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·D P Ruiz-GenaoA García-Díez
Jan 24, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·T Yamamoto, R Tsuboi
Sep 7, 2012·Case Reports in Medicine·Esra GuneyHuseyin Bayramlar
May 27, 1999·The Journal of Dermatology·C DurusoyE Yilmaz
Jul 16, 2014·Biotechnology & Genetic Engineering Reviews·Kamal SharmaGanesh Selvaraj Duraisamy
May 24, 2001·The American Journal of the Medical Sciences·R A Koppel, E E Boh
Feb 14, 2006·Seminars in Oncology·Aimee S PayneRaymond B Weiss
Apr 2, 2005·Clinics in Dermatology·Marti Jill RotheJane M Grant-Kels
Nov 1, 1996·Journal of the American Academy of Dermatology·J M Parsons
Feb 21, 2006·Journal of the American Academy of Dermatology·Anthony A Gaspari
Aug 16, 2000·Dermatologic Clinics·M J RotheJ M Grant-Kels
Feb 22, 2012·Annals of Dermatology·Eyassu Habte-Gabr, Nicolas Lecea
Jul 14, 2010·International Journal of Dermatology·Issam HamadahAbdulmajeed Alajlan
Oct 23, 1998·Journal of the European Academy of Dermatology and Venereology : JEADV·O AvciA T Guneş
Nov 27, 1999·Journal of Cutaneous Medicine and Surgery·D SassevilleS A Khenaizan
Dec 1, 1996·Seminars in Cutaneous Medicine and Surgery·R Prussick
Mar 15, 2002·American Journal of Clinical Dermatology·Philip R Cohen, Razelle Kurzrock
May 20, 1998·Dermatologic Clinics·R Stadler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.