PMID: 8600796Aug 1, 1995Paper

Cutaneous sclerotic fibroma. Immunohistochemical evidence of a fibroblastic neoplasm with ongoing type I collagen synthesis

The American Journal of Dermatopathology
P K ShitabataM R Wick

Abstract

The sclerotic fibroma (SF) is a tumor of the skin that may occur sporadically or in the context of Cowden's syndrome. The authors studied four examples of this tumor in an effort to understand better the nature of the fibrous matrix in SF and its significance. A novel antibody was utilized that is directed against the immunoreactive amino-terminal precuror domain of human type I procollagen (AP). This peptide is usually identified only at sites of active or recent collagen synthesis and deposition. All examples of SF showed strong cellular and stromal staining for AP. The matrix also demonstrated variable staining for type IV collagen and laminin. The overall immunophenotype of this lesion suggests that it may be a specialized fibroblastic ("dermal dendrocytic?") tumor. Despite its hypocellularity and hyalinized nature, SF is thought to exhibit ongoing matrical production that supports a neoplastic character for this lesion.

Citations

Jan 28, 1999·Cancer·M MichalM Miettinen
Jan 23, 2002·The American Journal of Dermatopathology·T Minsue ChenAlun R Wang
Nov 7, 2006·Journal of Cutaneous Pathology·Boncheol GooDaniel P Vandersteen
Sep 22, 2009·Journal of Cutaneous Pathology·Catherine M StefanatoJ Eduardo Calonje
Dec 23, 1999·The American Journal of Dermatopathology·P R CohenR J Cochran
May 29, 2004·The American Journal of Dermatopathology·Faizan Alawi, Paul D Freedman
Jun 12, 2008·Journal of Cutaneous Pathology·Keiko NakashimaOsamu Yamamoto
Jun 14, 2017·The American Journal of Dermatopathology·Sergio Santos-AlarcónLuis Requena
Mar 4, 2000·The American Journal of Dermatopathology·V N HanftV G Prieto
May 20, 1998·The American Journal of Surgical Pathology·P RudolphR Parwaresch
May 21, 2015·Einstein·Guilherme Flosi Stocchero
Nov 23, 2018·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Mamiko TosaRei Ogawa
Mar 26, 2003·The American Journal of Dermatopathology·Pierre RudolphReza Parwaresch
Oct 14, 2019·Journal of Cutaneous Pathology·Lucia KrivošíkováPavel Babál
Jul 27, 1999·The British Journal of Dermatology·P PillayR Chetty

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