Cutaneous short-interfering RNA therapy

Expert Opinion on Drug Delivery
B GeusensJ Lambert

Abstract

Since the 1990s, RNA interference (RNAi) has become a major subject of interest, not only as a tool for biological research, but also, more importantly, as a therapeutic approach for gene-related diseases. The use of short-interfering RNAs (siRNAs) for the sequence-specific knockdown of disease-causing genes has led to numerous preclinical and even a few clinical studies. Applications for cutaneous delivery of therapeutic siRNA are now emerging owing to a strong demand for effective treatments of various cutaneous disorders. Although successful studies have been performed using several different delivery techniques, most of these techniques encounter limitations for translation to the clinic with regards to patient compliance. This review describes the principal findings and applications in cutaneous RNAi therapy and focuses on the promises and pitfalls of the delivery systems.

References

Mar 1, 1990·The Medical Clinics of North America·R R Suskind
Oct 1, 1971·Physiological Reviews·R J Scheuplein, I H Blank
Jan 1, 1981·International Journal of Dermatology·P M Elias
Dec 1, 1995·Human Molecular Genetics·M Y Alexander, R J Akhurst
Jun 15, 1996·The Journal of Clinical Investigation·U R HenggeJ C Vogel
Jan 1, 1996·Skin Pharmacology : the Official Journal of the Skin Pharmacology Society·F DreherP Elsner
Apr 22, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·N KanikkannanP Ramarao
Sep 9, 1999·The Journal of Toxicological Sciences·M MoriC Furihata
Mar 4, 2000·Advanced Drug Delivery Reviews·R WattiauxM Jadot
May 16, 2000·The Journal of Gene Medicine·V BudkerJ A Wolff
Jun 6, 2000·Experimental Dermatology·J D Bos, M M Meinardi
Nov 4, 2000·Expert Opinion on Investigational Drugs·W Pfützner, J C Vogel
Nov 21, 2000·Human Gene Therapy·J Uitto, L Pulkkinen
Nov 10, 2001·Annual Review of Biomedical Engineering·D V McAllisterM R Prausnitz
May 7, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhengrong Cui, Russell J Mumper
Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal
Jun 21, 2002·Journal of Internal Medicine·P A KhavariA Vahlquist
Dec 7, 2002·Progress in Lipid Research·Joke A BouwstraMaria Ponec
Dec 26, 2002·The Journal of Biological Chemistry·Timothy A VickersBrenda F Baker
Jan 25, 2003·The Journal of Pharmacy and Pharmacology·Shawn BabiukMarianna Foldvari
Feb 8, 2003·Human Gene Therapy·John DileoLeaf Huang
Sep 27, 2003·Methods : a Companion to Methods in Enzymology·Kristina K PeachmanCarl R Alving
Oct 2, 2003·Biological & Pharmaceutical Bulletin·Yukihiko AramakiSeishi Tsuchiya
Jan 6, 2004·Nature Biotechnology·Pankaj KarandeSamir Mitragotri
Jan 16, 2004·Gene Therapy·E Basner-TschakarjanU R Hengge
Mar 17, 2004·Advanced Drug Delivery Reviews·Adrian C Williams, Brian W Barry
Mar 17, 2004·Advanced Drug Delivery Reviews·Gregor Cevc
Jun 23, 2004·Oncogene·Maria KarasaridesRichard Marais
Jul 31, 2004·Trends in Biotechnology·Zain Paroo, David R Corey
Sep 3, 2004·Mutation Research·Renu WadhwaKazunari Taira
Oct 22, 2004·Nature·Lincoln D Stein
Mar 3, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Hyun Kyoung KimJae-Ryong Kim
Mar 23, 2005·Cancer Research·Arati SharmaGavin P Robertson
May 18, 2005·Experimental Cell Research·Anthony L CookRichard A Sturm

❮ Previous
Next ❯

Citations

Jun 24, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Emilio Gonzalez-GonzalezRoger L Kaspar
Sep 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Tracy Hsu, Samir Mitragotri
Jul 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Dan ZhengAmy S Paller
Jul 3, 2010·Journal of Biomedical Science·Rasmus O Bak, Jacob G Mikkelsen
Jun 15, 2010·The AAPS Journal·Jie WangJessie L-S Au
Oct 13, 2012·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Indu Pal Kaur, Gaurav Sharma
Jan 18, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ming ChenSamir Mitragotri
Jan 25, 2013·Pharmaceutical Research·Fabiana Testa Moura de Carvalho VicentiniMaria Vitória Lopes Badra Bentley
May 12, 2011·Expert Opinion on Drug Delivery·M L González-Rodríguez, A M Rabasco
Mar 31, 2011·Expert Opinion on Drug Delivery·Mireille Van GeleJo Lambert
Nov 26, 2015·Expert Opinion on Drug Delivery·Ibrahim A AljuffaliJia-You Fang
Jan 15, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rosalind H E ChongJames C Birchall
Jun 27, 2012·Clinics in Plastic Surgery·Elizabeth KiwanukaElof Eriksson
Apr 26, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Barbara GeusensJo Lambert
Feb 15, 2011·Advanced Drug Delivery Reviews·Tarl W ProwMichael S Roberts
Jan 6, 2012·The Journal of Investigative Dermatology·Lisa A DeLouise
Jan 21, 2011·The Journal of Investigative Dermatology·Robyn P HickersonRoger L Kaspar
Oct 28, 2016·Advances in Wound Care·Rabab A CharafeddineDavid J Sharp
Feb 23, 2012·Scientific Reports·Emilio González-GonzálezRoger L Kaspar
Mar 3, 2012·Experimental Dermatology·Maria Nascimento PrimoJacob Giehm Mikkelsen
May 7, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Pinaki R DesaiMandip Singh
Aug 22, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Woan-Ruoh LeeJia-You Fang
Dec 3, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Vikas HegdeDeena M Leslie Pedrioli
Aug 30, 2018·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Maria J KowzunDaniel J Ceradini
Apr 19, 2011·Nature Reviews. Genetics·Beverly L Davidson, Paul B McCray
Sep 1, 2020·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Leila HosseinzadehMasoud Sadeghi
Mar 13, 2014·Pigment Cell & Melanoma Research·Reinhart SpeeckaertNanja van Geel
Sep 7, 2017·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Paul Lawrence, Joseph Ceccoli
Oct 11, 2020·Pharmaceuticals·Muhammad Imran SajidRakesh Kumar Tiwari

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

© 2022 Meta ULC. All rights reserved