[Cutaneous side effects of the multikinase inhibitors sorafenib and sunitinib].

Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
A WollenbergT Eames

Abstract

Molecular targeted therapy with monoclonal antibodies and low molecular weight inhibitors is gaining increasing importance particularly in the treatment of malignant tumors. These drugs are specific and highly selective agents that intervene in the dysfunctional regulatory processes of malignant cells in order to influence cell proliferation, cell differentiation, or angiogenesis. The multikinase inhibitors sorafenib and sunitinib exhibit a favorable tolerability profile and spectrum of side effects, especially in comparison to conventional chemotherapeutic agents. However, they induce specific cutaneous side effects that can in turn be indicators of antitumor activity. This review article compares the cutaneous side effects of the two multikinase inhibitors sorafenib and sunitinib and discusses the therapeutic options for the individual cutaneous reaction patterns.

References

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Citations

Apr 20, 2011·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A DegenR Gutzmer
Jun 8, 2013·Der Urologe. Ausg. A·G J Burbach, T Zuberbier
May 14, 2014·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·K Maleki, E Weisshaar
May 14, 2014·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·L M EhmannB Homey
Nov 27, 2019·Journal of Cosmetic Dermatology·Athanasia VarvaresouSpyros Papageorgiou
Mar 16, 2012·Deutsches Ärzteblatt International·Ralf GutzmerAlexander Kapp

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