Cutaneous solitary neural hamartoma: report of an unusual case

The American Journal of Dermatopathology
Ayman Al HabeebDanny Ghazarian

Abstract

Cutaneous hamartomas are tumor-like proliferations of tissue indigenous to the organ but arranged abnormally. There are examples in the literature of cutaneous hamartomas composed of a variety of different components. To our knowledge, there is no previous report of such cutaneous solitary neural hamartoma. Our case occurred in a 51-year-old man with pain and paresthesia in the right shoulder associated with a nodule that was surgically removed. There was no history of trauma, other skin nodules, neurofibromatosis, or tuberous sclerosis. Histologically, there was an unencapsulated nodule, composed of mature nerve bundles noted abnormally high within the papillary dermis, extending to the reticular dermis with periadnexal distribution. Immunohistochemically, the nerve bundles were positive for S-100, including the smaller nerve twigs, and the perineurium was highlighted by epithelial membrane antigen, reminiscent of normal peripheral nerves. Although, neural components including mature nerve bundles have been described in various cutaneous hamartomas, this represents a peculiar case of a cutaneous mature peripheral nerve hamartoma. Whether this is related to other entities of cutaneous hamartomas (ie, neurofollicular hamartoma, ...Continue Reading

References

Oct 1, 1991·The American Journal of Dermatopathology·M P NovaA Halperin
Dec 1, 1989·Journal of Cutaneous Pathology·R J Barr, M M Goodman
Nov 1, 1982·The Journal of Investigative Dermatology·R K Winkelmann, J A Carney
Jun 1, 1994·The American Journal of Dermatopathology·M Megahed
Apr 1, 1994·The American Journal of Dermatopathology·O P Sangueza, L Requena
Jun 1, 1993·The American Journal of Dermatopathology·P Donati, L Balus
Jul 1, 1997·The Journal of Dermatology·M Toyoda, M Morohashi
Mar 4, 1998·Archives of Otolaryngology--head & Neck Surgery·J C Tiffee, E L Barnes
Jun 27, 1998·Pathology·P K RamdialA Madaree
Dec 5, 1998·Pathology·G H MasonE Tay
Jun 24, 1999·The American Journal of Dermatopathology·D L XieA B Hessel
Mar 3, 2004·Neuroradiology·P H LaiH B Pan
Mar 23, 2004·Journal of the American Academy of Dermatology·Ignacio Sanchez-CarpinteroPaula E North
Aug 4, 2005·The Journal of Craniofacial Surgery·Afşin UysalTülin Yalta
Apr 20, 2006·The Journal of Dermatology·Manabu HamadaMasutaka Furue
Jun 17, 2006·The American Journal of Dermatopathology·Seung Yoon LeeSook Ja Son
May 17, 2007·Journal of the American Academy of Dermatology·Payam SaadatManjunath S Vadmal
Aug 28, 2007·The American Journal of Surgical Pathology·Alessandra F Nascimento, Christopher D M Fletcher

❮ Previous
Next ❯

Citations

Dec 22, 2012·Case Reports in Dermatological Medicine·Nebojsa Arsenovic, Anuradha Sheth
Jun 28, 2014·BMJ Case Reports·Montasir JunaidSaroona Haroon
Jun 20, 2017·Journal of Cutaneous Pathology·Stephanie J T ChenDouglas R Fullen
Jun 13, 2018·The American Journal of Dermatopathology·Alejandro Lobato-BerezoMaría Teresa Fernández-Figueras

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Related Papers

Journal of the American Academy of Dermatology
Payam SaadatManjunath S Vadmal
The American Journal of Dermatopathology
Omar P Sangueza, Luis Requena
The American Journal of Dermatopathology
E Calonje, C D Fletcher
The Journal of Craniofacial Surgery
Afşin UysalTülin Yalta
© 2021 Meta ULC. All rights reserved