Cutaneous T-cell lymphoma cells are sensitive to rapamycin

Experimental Dermatology
Melanie KremerBarbara S Schnierle

Abstract

Cutaneous T-cell lymphomas (CTCL) are characterised by clonal expansion of helper T lymphocytes that infiltrate the skin. Only a small number of cell lines exist to study cellular pathways leading to T-cell transformation and to identify new targets for intervention. We wanted to investigate the inhibition of mTOR as a possible therapeutic target in CTCL. Primary cells of patients with Sézary syndrome (SS) and conventional CTCL cell lines were analysed. Constitutive activation of mTOR was found, and concomitantly, we could show that rapamycin, a specific inhibitor of mTOR, inhibits CTCL cell growth in vitro by induction of cell cycle arrest. Using a previously established animal model for CTCL, we additionally observed upon rapamycin treatment tumor growth inhibition in vivo. In summary, primary cells from patients with SS as well as CTCL cell lines allowed us to identify mTOR as an important target for intervention.

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Citations

Dec 14, 2011·The Journal of Investigative Dermatology·Reinhard DummerMaria B Karpova
Apr 22, 2015·The Journal of Investigative Dermatology·Wasakorn KittipongdajaStefan M Schieke
Feb 20, 2014·Oral Diseases·Z NudelmanR Czerninski
Mar 12, 2015·Cancer Chemotherapy and Pharmacology·Zakhar NudelmanRakefet Czerninski
Mar 15, 2015·Journal of the American Academy of Dermatology·Alexander L FogelJoyce M C Teng
May 21, 2013·Journal of the American Academy of Dermatology·Georgia LevidouPenelope Korkolopoulou
Oct 5, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·M MascoloS Staibano
Apr 5, 2019·Oncology Letters·Cristiana TanaseRadu Albulescu
Nov 16, 2019·European Journal of Pharmacology·Michał AntoszczakAdam Huczyński

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