PMID: 6160893Feb 1, 1981Paper

Cutaneous T cell lymphoma: characterization by monoclonal antibodies.

Blood
P C KungR L Edelson

Abstract

Monoclonal antibodies to human T cells permit the characterization of the surface phenotype of cutaneous T cell lymphoma (CTCL). The majority of CTCL cells are reactive with OKT1 and OKT3 monoclonals, which identify peripheral T cells and mature thymocytes. The neoplastic cells also react with OKT4, which recognizes the inducer T cell subset; they are, however, unreactive with OKT5 monoclonal, which identifies cytotoxic/suppressor T cell subsets. These data are in agreement with previous functional studies demonstrating that CTCL is a neoplasm of inducer (helper) T cells.

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
E L ReinherzS F Schlossman
The Journal of Immunology : Official Journal of the American Association of Immunologists
E R RichieD K Dennison
© 2021 Meta ULC. All rights reserved