PMID: 107864Mar 1, 1979

Cutaneous T-cell lymphoma in association with a monoclonal gammopathy

Archives of Dermatology
M V JoynerP Audoly

Abstract

Monoclonal gammopathies and other abnormalities of immunoglobulin production may characterize or frequently be associated with B-cell lymphoproliferative disorders. We describe a patient with a T-cell cutaneous lymphoma, expressed clinically as Sézary's syndrome, in association with an immunoglobulin A type kappa M-component monoclonal gammopathy. No evidence for the coincident presence of a malignant plasma dyscrasia was found. This clinical association may lend clinical support to the concept that Sézary's syndrome is a T-helper-cell malignant proliferation. A colonic carcinoma was also present, possibly representing a second manifestation of a functionally abnormal cellular immune system.

Citations

Oct 1, 1984·Journal of the American Academy of Dermatology·P Y VenencieA Puissant
Nov 1, 1994·Journal of the American Academy of Dermatology·F GrangeL Vaillant
Nov 15, 1982·Cancer·E BryantI A Iossifides
Jan 1, 1981·Archives of Dermatological Research·J P CassutoM Schneider
Oct 1, 1987·The Journal of Dermatology·R L Edelson

Related Concepts

Hypergammaglobulinemia
IgA2
Kappa-Immunoglobulin Subgroup VK-21
Immunoglobulin Light Chains
Mycosis Fungoides
Sezary Syndrome
Malignant Neoplasm of Skin
T-Lymphocyte

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