Cutaneous T-cell lymphoma, multilobated type, expressing membrane differentiation antigens of precursor T-lymphocytes

The British Journal of Dermatology
S C Van der PutteJ Toonstra

Abstract

Monoclonal antibodies to human T-cell membrane antigens were used to evaluate the immunological phenotype of the tumour cells in two cases of a recently described cutaneous T-cell lymphoma of 'multilobated' type. In one case the distinctive abnormal blast cells expressed positivity for OKT6, anti-HTAI, OKT4 and Leu-3a, and showed binding capacity for peanut agglutinin (PNA). These are properties normally displayed by immature cortical thymocytes. The antigen expression of the abnormal blast cells in the other case was OKT3, Leu-I, OKT4, Leu-3a in the absence of PNA-binding; these properties bear more resemblance to more mature T-inducer/helper cells. When combined with consideration of the morphological aspects we suggest that in both cases the abnormal cells represented precursor T-lymphocytes.

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Citations

Jun 1, 1997·The American Journal of Dermatopathology·A V MarzanoE Berti
Jan 1, 1985·Archives of Dermatological Research·S C van der PutteJ A van Unnik
Jan 1, 1984·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·S C van der PutteJ A van Unnik
Aug 1, 1988·Journal of the American Academy of Dermatology·E BertiP Vezzoni
Mar 1, 1987·Baillière's Clinical Haematology·J P Sloane
Nov 1, 1985·The British Journal of Dermatology·A FattorossiB Giannotti
Apr 1, 1988·Cancer·J van BaarlenJ A van Unnik
Feb 1, 1984·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J E VeldmanE H Huizing
Oct 1, 1984·International Journal of Dermatology·N C McFadden

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