PMID: 16511800Mar 3, 2006Paper

Cutaneous transmissible venereal tumor without genital involvement in a prepubertal female dog

Veterinary Clinical Pathology
R MarcosE Rocha

Abstract

An 11-month-old prepubertal crossbreed female dog was presented with multiple nodular lesions disseminated over the cervical, back, flank, and abdominal regions. The lesions were ulcerated and cauliflowerlike, or nodular and subcutaneous, measuring up to 13 cm in diameter. Cytologic preparations of one of the lesions revealed a uniform population of round to oval cells, with lightly basophilic cytoplasm that contained multiple distinct vacuoles. Frequent mitotic figures and occasional lymphocytes were also observed. The cytologic diagnosis was cutaneous transmissible venereal tumor (TVT) in a progressing growth phase. This was confirmed by histologic and immunohistochemical findings. Vaginal TVT was diagnosed later in the dog's mother. TVT is a contagious neoplasm of sexually mature dogs that usually is transmitted by coitus and affects the genital mucosa. To our knowledge, this is the first report of naturally occurring multicentric TVT in a prepubertal female dog and also is unique in its exclusively cutaneous (no mucosal) involvement. We speculate that transmission of neoplastic cells occurred during cohabitation and social/mothering behavior between the dogs. Despite the atypical clinical presentation, response to chemother...Continue Reading

Citations

Aug 29, 2013·Veterinary and Comparative Oncology·B GangulyA K Das
Dec 22, 2015·Trends in Genetics : TIG·Elaine A OstranderGary K Ostrander
Apr 15, 2016·The Journal of Veterinary Medical Science·Chanokchon SetthawongsinAnudep Rungsipipat
Dec 4, 2019·Journal of the American Veterinary Medical Association·Jessica A FragolaGillian C Shaw
Sep 15, 2018·Journal of Comparative Pathology·C SetthawongsinS Techangamsuwan
Nov 14, 2021·The Veterinary Record·Danielle N GibsonDavid R Killick

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