PMID: 9546960Jan 1, 1997Paper

Cutaneous vascular responses to acetylcholine are mediated by a prostanoid-dependent mechanism in man

Vascular Medicine
F KhanJ J Belch

Abstract

Approximately 50% of the forearm vasodilatation to intra-arterial infusions of acetylcholine is mediated by endothelium-derived nitric oxide. These conclusions have been derived from venous occlusion plethysmographic measurements of total forearm blood flow during co-infusions of acetylcholine and NG-monomethyl-L-arginine (L-NMMA), an inhibitor of nitric oxide synthase. Since venous occlusion plethysmography measures total limb blood flow, the relative proportion of the measurement from skin cannot be determined precisely. To determine the effects of acetylcholine on skin specifically, we have used laser Doppler flowmetry to measure vascular responses to local iontophoresis of acetylcholine in the forearm of normal male volunteers. To elucidate the possible mechanisms of cutaneous vasodilatation to acetylcholine, vascular responses were measured before and after systemic inhibition of prostanoid production and nitric oxide synthesis by oral aspirin (600 mg daily for 3 days) and intravenous L-NMMA (3 mg/kg for 60 min), respectively. After aspirin administration, dose-dependent vascular responses to acetylcholine were reduced significantly by approximately 53% (p < 0.005, ANOVA). In contrast, intravenous L-NMMA appeared to have n...Continue Reading

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Citations

Aug 31, 1999·Journal of Hypertension·P M Vanhoutte
Jun 30, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Katalin FarkasIstván Kiss
Jun 23, 2009·The British Journal of Dermatology·M ShibasakiC G Crandall
Apr 6, 2004·Medicine and Science in Sports and Exercise·Helena Lenasi, Martin Strucl
Jan 18, 2002·Journal of Applied Physiology·Martin BerghoffRoy Freeman
Jan 22, 2005·The Journal of Physiology·Lacy A HolowatzW Larry Kenney
Mar 2, 2005·Obstetrics and Gynecology·Judith BlaauwJan G Aarnoudse
Nov 6, 2010·Clinical Endocrinology·J SassariniM A Lumsden
Aug 19, 2007·Journal of Clinical Monitoring and Computing·Michael J GesquiereKirk H Shelley
Feb 24, 2001·International Journal of Clinical & Laboratory Research·A CupistiG Barsotti
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Shubha Shastry, Michael J Joyner
Feb 27, 2003·Aging Clinical and Experimental Research·Marco RossiFerdinando Pentimone
Sep 3, 2003·Clinical Physiology and Functional Imaging·Faisel KhanJill J F Belch
Jan 15, 2005·Journal of Applied Physiology·D L KelloggJ V Green
Nov 8, 2011·Pain·Julien PelletierDominique Sigaudo-Roussel
Feb 25, 2006·Journal of Vascular Research·Kim M GoodingAngela C Shore
Nov 28, 2014·Physiological Reports·Malia S Q MurphyGraeme N Smith
Jul 20, 1999·European Journal of Clinical Investigation·G KennedyJ J Belch
Dec 18, 2001·Journal of Cardiovascular Pharmacology·Jane Elizabeth RamsayNaveed Sattar
Jan 20, 2007·European Journal of Pain : EJP·Jörn SchattschneiderRalf Baron
Jun 26, 2003·The Journal of Physiology·Faisel KhanJill J F Belch
Nov 26, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Maylis TartasPierre Abraham
Mar 13, 2003·Kidney International·Karen E PaisleyAngela C Shore

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