PMID: 7524993Aug 1, 1994Paper

Cutaneous vasodilatation induced by nitric oxide-evoked stimulation of afferent nerves in the rat

British Journal of Pharmacology
P Holzer, M Jocic

Abstract

1. The site of action at which nitric oxide (NO) may contribute to neurogenic vasodilatation in the hindpaw skin of urethane-anaesthetized rats was examined by the use of NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of NO synthase. 2. Skin blood flow was measured by laser Doppler flowmetry, and neurogenic vasodilatation was evoked either by topical application of mustard oil (5%) or antidromic electrical stimulation of the saphenous nerve (antidromic vasodilatation). 3. L-NAME (60 mumol kg-1, i.v.) attenuated the hyperaemia evoked by mustard oil in an enantiomer-specific manner but failed to reduce antidromic vasodilatation and the vasodilatation due to i.v. injected calcitonin gene-related peptide (CGRP) and substance P (0.1-1 nmol kg-1 each), two proposed mediators of neurogenic vasodilatation. 4. Pretreatment of rats with capsaicin (125 mg kg-1, s.c. 2 weeks beforehand), to defunctionalize afferent neurones, reduced the hyperaemic response to mustard oil and prevented L-NAME from further decreasing the vasodilatation evoked by mustard oil. 5. Intraplantar infusion of sodium nitroprusside (SNP, 0.15 nmol in 1 min), a donor of NO, induced hyperaemia which was significantly diminished by the CGRP antagonist CGRP8-37 ...Continue Reading

References

Dec 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·F Lembeck, P Holzer
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·V M VergeT Hökfelt
Dec 1, 1992·Acta Physiologica Scandinavica·P Delay-GoyetJ M Lundberg
Nov 1, 1990·British Journal of Pharmacology·D D ReesS Moncada
Dec 4, 1990·European Journal of Pharmacology·S R HughesS D Brain
Jun 1, 1989·British Journal of Pharmacology·J V EspluguesS Moncada
May 1, 1993·British Journal of Pharmacology·S M MoussaouiC Garret
Jan 1, 1994·The Journal of Comparative Neurology·M A VizzardW C De Groat
Feb 1, 1993·Journal of Autonomic Pharmacology·C A MaggiA Giachetti

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Citations

Feb 19, 1997·European Journal of Pharmacology·M UchiyamaN Toda
Apr 23, 1997·European Journal of Pharmacology·E PintérJ Szolcsányi
Aug 27, 1997·European Journal of Pharmacology·H InoueY Koshihara
Feb 11, 1998·General Pharmacology·P Holzer
Jan 7, 2006·Cephalalgia : an International Journal of Headache·J N J M de HoonL M A B Van Bortel
Nov 1, 1995·British Journal of Pharmacology·P HolzerB A Peskar
Mar 12, 2010·BMC Neurology·Fabrizio VernieriClaudio Pedone
Jan 22, 2005·European Journal of Pharmacology·Andrew D GrantSusan D Brain
Jul 27, 2001·Diabetes Care·A I VinikG L Pittenger
Aug 18, 2000·The Tohoku Journal of Experimental Medicine·H SuzukiH Izumi
Dec 1, 1994·Cephalalgia : an International Journal of Headache·M A Moskowitz, F M Cutrer
May 30, 2003·Pharmacological Reviews·Noboru Toda, Tomio Okamura
Jul 1, 1995·Canadian Journal of Physiology and Pharmacology·P HolzerM K Herbert
Jul 18, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·M J MillerM Sandoval
Jun 19, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·U C KoppT Hökfelt
Feb 15, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brett J Wong
Jun 20, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Brett J WongArshed A Quyyumi
Feb 26, 2019·Pain Reports·Julia ForstenpointnerRalf Baron
Sep 1, 2004·BioTechniques·Nuray Erin, Gary A Clawson

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