Cutaneous vasomotor effects of neuropeptide Y

Neuropeptides
M A Hashim, A S Tadepalli

Abstract

The effects of neuropeptide Y (NPY) were examined on the cutaneous microvascular blood flow (CMF) of the hindpaws in anesthetized rats. NPY (0.5-50 nmol/kg), infused intra-arterially into the hindpaw circulation, produced sustained dose-dependent increases in CMF (29 +/- 7% to 210 +/- 52%) indicating cutaneous vasodilation. Denervation of a hindpaw, ganglionic or alpha-adrenergic blockade significantly elevated the resting CMF indicating tonic vasoconstrictor sympathetic input to the cutaneous vasculature. In the denervated hindpaw or following ganglionic blockade, NPY produced sustained decreases in CMF (up to 51 +/- 8%) indicating vasoconstriction. Effects of the Y1 receptor agonist, (Leu31, Pro34) NPY were identical to those of NPY. The Y2 receptor agonist, NPY13-36 increased CMF of the intact hindpaw (24 +/- 10%-68 +/- 16% at 5-150 nmol/kg, i.a.) but did not affect CMF of the denervated hindpaw. NPY and (Leu31, Pro34)NPY, but not NPY13-36, produced significant pressor effects. These data suggest that: 1) NPY produces neurogenic cutaneous vasodilation via presynaptic Y2 receptor-mediated inhibition of sympathetic tone, 2) Y1 receptors may also exist presynaptically, however, it is likely that (Leu31, Pro34)NPY does not disti...Continue Reading

Citations

Oct 10, 2002·Neuropeptides·R W LambertR D Granstein
Feb 23, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R AbounaderE Hamel
Jul 13, 2002·The Journal of Comparative Neurology·Hideki MatsudaTomas Hökfelt
Oct 19, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jérémy ChéretChristelle Le Gall-Ianotto
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Dan P StephensJohn M Johnson
Mar 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·D P StephensJ M Johnson
Oct 11, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ulrich Nordheim, Karl G Hofbauer
May 29, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Dan P StephensJohn M Johnson

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