Cutoff levels of immunoglobulin M antibody against viral core antigen for differentiation of acute, chronic, and past hepatitis B virus infections.

Journal of Clinical Microbiology
W H GerlichR Thomssen

Abstract

The titer of antibody against core antigen of hepatitis B virus in the immunoglobulin M class (IgM anti-HBc) was determined by an IgM capture assay of reduced sensitivity (30 arbitrary units). The distribution of titers among 235 acute hepatitis patients who were hepatitis B surface antigen (HBsAg) positive suggested that 600 U forms a lower cutoff value for acute hepatitis B. Clinically apparent cases of acute hepatitis with high IgM anti-HBc and without HBsAg were rare (2.6%). Acute, non-B hepatitis in HBsAg carriers was more frequent (9.4%). In chronic hepatitis B, 39% of 174 biopsy-proven cases had moderate titers of 30 to 600 U, whereas healthy HBsAg carriers were rarely (4/84) positive. In mild or inapparent infections without HBsAg, titers were between 50 and 400 U. Thus, sufficiently accurate and sensitive quantitation of IgM anti-HBc allows for differentiation of acute and nonacute hepatitis B virus infection in acute hepatitis, partial differentiation between clinically symptomatic and asymptomatic chronic infections, and identification of recent subclinical infections.

References

Jan 1, 1978·Journal of Medical Virology·B J Cohen
Nov 1, 1977·Klinische Wochenschrift·W H GerlichR Thomssen
Mar 1, 1985·Annals of Internal Medicine·S C GordonE R Schiff
Apr 1, 1985·Journal of Virological Methods·P Kryger
May 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P BänningerM Schmid
Jan 1, 1984·Journal of Medical Virology·G PapaevangelouP Stathopoulou
Mar 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K H ChauL R Overby
Dec 1, 1981·The Journal of Infection·P P MortimerR S Tedder
Jun 15, 1981·Klinische Wochenschrift·H H DromeyerK H Meyer zum Büschenfelde
Jan 1, 1981·Journal of Medical Virology·R CappelS Cadranel
Apr 1, 1981·The Journal of Hygiene·R S Tedder, R Wilson-Croome

❮ Previous
Next ❯

Citations

Jan 1, 1990·Medical Microbiology and Immunology·R DeepenW H Gerlich
Dec 1, 1991·Journal of Clinical Pathology·D J Morris
Jul 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Z IbarraV Carreño
May 18, 2006·Journal of Gastroenterology and Hepatology·Yi-Wen HuangDing-Shinn Chen
May 8, 2009·International Journal of Epidemiology·Adela Paez JimenezArnaud Fontanet
May 25, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Irene CacciolaGiovanni Raimondo
Jan 11, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Ankur JindalShiv K Sarin
Jul 23, 2013·Virology Journal·Wolfram H Gerlich
May 1, 1991·Journal of Clinical Pathology·K JobstA Horvath
Oct 1, 1988·La Ricerca in Clinica E in Laboratorio·F BoninoE Chiaberge
Jul 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J A QuirogaV Carreño
Dec 5, 2014·World Journal of Gastroenterology : WJG·Cyriac Abby Philips, Shiv Kumar Sarin
Nov 20, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R A A Pondé
Sep 9, 2017·Archives of Virology·Robério Amorim de Almeida Pondé
Dec 21, 2018·Journal of Immunoassay & Immunochemistry·Stephen Oluwasegun AdetunjiOluwasola Akinniyi
Mar 23, 2021·Journal of Immunoassay & Immunochemistry·Oluwasola Grace AkinniyiEmmanuel Donbraye

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the National Cancer Institute
E TaborL F Barker
Acta Medica Iranica
M TabarestaniA Afkari
Zhurnal mikrobiologii, epidemiologii, i immunobiologii
M I MikhaĭlovM P Amarian
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
A L ZignegoG La Villa
Mikrobiyoloji bülteni
Koray Ergünay
© 2021 Meta ULC. All rights reserved