Cutting Edge: Batf3 Expression by CD8 T Cells Critically Regulates the Development of Memory Populations.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Zhijuan QiuBrian S Sheridan

Abstract

The basic leucine zipper transcription factor ATF-like 3 (BATF3) is required for the development of conventional type 1 dendritic cells that are essential for cross-presentation and CD8 T cell-mediated immunity against intracellular pathogens and tumors. However, whether BATF3 intrinsically regulates CD8 T cell responses is not well studied. In this article, we report a role for cell-intrinsic Batf3 expression in regulating the establishment of circulating and resident memory T cells after foodborne Listeria monocytogenes infection of mice. Consistent with other studies, Batf3 expression by CD8 T cells was dispensable for the primary response. However, Batf3 -/- T cells underwent increased apoptosis during contraction to contribute to a substantially reduced memory population. Batf3 -/- memory cells had an impaired ability to mount a robust recall response but remained functional. These findings reveal a cell-intrinsic role of Batf3 in regulating CD8 T cell memory development.

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Citations

Sep 30, 2020·Nature Immunology·Caleb A Lareau, Ansuman T Satpathy
Oct 13, 2020·Frontiers in Immunology·Jessica Nancy ImperatoBrian S Sheridan
Jan 23, 2021·Annual Review of Immunology·Mar Cabeza-CabrerizoCaetano Reis E Sousa
May 24, 2021·Seminars in Immunology·Ariel E Marciscano, Niroshana Anandasabapathy
Jun 5, 2021·ELife·Christopher Duncan-LewisBritt A Glaunsinger
Aug 12, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Federico SimonettaRobert S Negrin

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