Cutting Edge: CD28 controls dominant regulatory T cell activity during active immunization

The Journal of Immunology : Official Journal of the American Association of Immunologists
Clay LyddaneMichel Sadelain

Abstract

Ligation of CD28 during Ag recognition plays an important role in the generation of effective T cell responses. However, its peripheral control of regulatory T cell function remains obscure. In this study, we show that naive wild-type or CD28(-/-) CD4(+)CD25(-) T cells exposed to peptide in vivo develop regulatory activity that suppresses the response of adoptively transferred naive T cells to a subsequent immunogenic challenge. We find that although CD28 is engaged during the initial peptide-priming event and is essential to sustain T cell survival, it is not sufficient to prevent the dominance of regulatory T cell function. Immunization with adjuvant abrogates regulatory dominance, reducing overall Foxp3 expression in a CD28-dependent manner. We conclude that CD28 licenses active immunization by regulating Ag-induced immunoregulation.

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Citations

Jan 3, 2013·The Journal of Clinical Investigation·Ruan ZhangLaurence A Turka
Aug 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tatiana N GolovinaJames L Riley
Dec 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carole GuillonneauBernard Vanhove
Jul 14, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T ZhangA M Azimzadeh

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