PMID: 15383555Sep 24, 2004Paper

Cutting edge: heterozygote advantage in autoimmune disease: hierarchy of protection/susceptibility conferred by HLA and killer Ig-like receptor combinations in psoriatic arthritis

The Journal of Immunology : Official Journal of the American Association of Immunologists
George W NelsonMary Carrington

Abstract

Functionally relevant combinations of HLA and killer Ig-like receptor (KIR) genotypes influence resistance to several diseases in humans. Analysis of genetic data from such studies is challenging because it involves multiple linked and unlinked loci that exert their influence in an epistatic manner. We previously reported that subjects with certain activating receptors were susceptible to developing psoriatic arthritis (PsA), an effect that was strongest when HLA ligands for corresponding homologous inhibitory receptors were missing. In this study, we present a novel model in which susceptibility to PsA is determined by the overall balance of activating and inhibitory composite KIR-HLA genotypes. This model fits our knowledge of clonal NK cell expression of KIR and regulation of NK cell activity better than does the previous model, as reflected in a robust trend for increasing susceptibility to PsA with more activating genotypes. These data emphasize the remarkable influence of KIR/HLA combinations on this disease.

References

Jul 1, 1990·Immunology Today·H G Ljunggren, K Kärre
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·M Valés-GómezJ Strominger
Jun 19, 2001·Current Opinion in Immunology·L L Lanier
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heather G ShillingPeter Parham
Jul 23, 2002·Nature Genetics·Maureen P MartinMary Carrington
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maureen P MartinMary Carrington

❮ Previous
Next ❯

Citations

Feb 19, 2005·Nature Reviews. Immunology·Peter Parham
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wim JennesLuc Kestens
Jan 26, 2007·Annals of Neurology·Tai Wai YeoStephen Sawcer
Dec 21, 2007·International Journal of Immunogenetics·Clair M Gardiner
Mar 25, 2009·Genetic Testing and Molecular Biomarkers·Rami A R MahfouzRoy A Khalaf
Mar 3, 2010·Immunogenetics·Philip H KruseLutz Walter
May 19, 2010·Expert Review of Clinical Immunology·Esin AktasGunnur Deniz
Nov 3, 2010·Immunology·Nicolas SchleinitzEric Vivier
Jan 25, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cornelia RosnerLutz Walter
Jan 26, 2012·Clinical Reviews in Allergy & Immunology·Vinod Chandran
May 16, 2015·PLoS Neglected Tropical Diseases·Christiane Maria AyoAna Maria Sell
Jan 13, 2017·Journal of Immunology Research·Sara GabrielliLoris Zamai
Jul 25, 2018·Current Protocols in Immunology·Roberto Biassoni, Mauro S Malnati
Mar 20, 2020·Molecular Diagnosis & Therapy·Vittorio BolcatoValeria Brazzelli
Oct 6, 2020·Journal of Immunology Research·Fereshteh BeigmohammadiNima Rezaei
Jul 28, 2005·Current Rheumatology Reports·Eleanor Korendowych, Neil McHugh
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph Kaplan, Susan Land
Mar 29, 2007·The British Journal of Dermatology·Y T ChangS F Tsai
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vaughan P WittmanJon A Weidanz
Aug 2, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R HanvesakulD Briggs
Feb 3, 2009·Nature Clinical Practice. Rheumatology·Kristine E NogralesAnne M Bowcock
May 31, 2006·Immunogenetics·Marija VelickovicHeather Dunckley
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph H ChewningBo Dupont
Dec 21, 2007·Clinical Reviews in Allergy & Immunology·Brian J NickoloffFrank O Nestle
Aug 30, 2011·Cellular and Molecular Life Sciences : CMLS·Stephanie M WoodYenan T Bryceson
Mar 29, 2008·Pharmacogenomics·Proton Rahman, Darren D O'Rielly
Jan 20, 2010·International Journal of Immunogenetics·M JobimG Schwartsmann
Sep 8, 2010·Cellular & Molecular Immunology·Ivan V ZvyaginDmitriy M Chudakov
Nov 9, 2011·Nature Reviews. Rheumatology·Darren D O'Rielly, Proton Rahman
Jun 21, 2011·Journal of Biomedicine & Biotechnology·Sinéad Dunphy, Clair M Gardiner
Jan 1, 2012·Annals of Vascular Diseases·Naoyuki Tsuchiya

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.