Cutting Edge: Hormonal milieu, not antigenic specificity, determines the mature phenotype of autoreactive B cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
Jeganathan VenkateshBetty Diamond

Abstract

Although both marginal zone and follicular B cells produce anti-DNA Abs in murine models of systemic lupus erythematosus, it has been unclear whether these distinct B cell subsets make identical or different Abs. Single-cell analysis demonstrates that the same DNA-reactive B cells can mature to either subset, depending on the hormonal environment. Anti-DNA B cells in estradiol-treated mice become marginal zone cells while identical cells from prolactin-treated mice become follicular cells. The B cell receptor signaling pathway is influenced by hormonal milieu. Thus, hormonal milieu and perhaps B cell receptor signaling, but not antigenic specificity, correlates with the differentiation pathway. These observations have implications for the pathogenesis and treatment of autoimmune disease.

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Citations

Oct 5, 2012·Annals of Neurology·Jorge CorrealeMaría C Ysrraelit
Aug 22, 2006·Scandinavian Journal of Immunology·D S Pisetsky, N Jiang
Jun 19, 2008·Environmental Health Perspectives·Glinda S CooperNoel R Rose
Nov 28, 2012·Nature Reviews. Endocrinology·Sanaz SakianiWilliam J Kovacs
Mar 30, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeganathan VenkateshBetty Diamond
Feb 14, 2009·The EMBO Journal·Christian SchmidtPhilip W Tucker
Nov 26, 2009·Clinical Reviews in Allergy & Immunology·Subhrajit SahaElena Peeva
Feb 25, 2009·Annals of the New York Academy of Sciences·Istvan BercziKalman Kovacs
May 2, 2007·Arthritis and Rheumatism·Michael D Lockshin, UNKNOWN Mary Kirkland Center for Lupus Research Consortium
Nov 3, 2006·Clinical and Vaccine Immunology : CVI·Jian ZhangZhigang Tian
Dec 27, 2008·The Journal of Investigative Dermatology·Kerstin FoitzikRalf Paus

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