Cutting edge: KIR antisense transcripts are processed into a 28-base PIWI-like RNA in human NK cells.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Frank CichockiJ S Miller

Abstract

Killer Ig-like receptors (KIRs) are expressed in a variegated, clonally restricted fashion on NK cells and are important determinants of NK cell function. Although silencing of individual KIR genes is strongly correlated with the presence of CpG dinucleotide methylation within the promoter, the mechanism responsible for silencing has not been identified. Our results show that antisense transcripts mediate KIR transcriptional silencing through a novel PIWI-like 28-base small RNA. Although PIWI RNA-mediated silencing of transposable elements within germ cells have been described, this is the first report that identifies a PIWI-like RNA in an immune somatic cell lineage and identifies a mechanism that may be broadly used in orchestrating immune development.

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Citations

May 7, 2011·Nucleic Acids Research·Zheng YanPhilipp Khaitovich
Mar 18, 2011·Journal of Innate Immunity·Frank CichockiStephen K Anderson
Jun 13, 2013·Critical Reviews in Immunology·Geraldine M O'Connor, Daniel McVicar
Sep 17, 2013·International Immunology·Chelsea L DavidsonDeborah N Burshtyn
Jul 25, 2013·Antioxidants & Redox Signaling·Guohui WanXiongbin Lu
Sep 3, 2014·Molecular Therapy. Nucleic Acids·Stephen K Anderson
Jan 19, 2013·Genes and Immunity·S R PresnellC T Lutz
Jul 19, 2013·Genes and Immunity·P W WrightS K Anderson
Oct 8, 2016·Transcription·Didier Auboeuf
Jan 25, 2017·Nucleic Acids Research·Erika GirardiRonald P van Rij
Mar 5, 2016·International Journal of Molecular Sciences·Alexander SchenkPhilipp Zimmer
Sep 22, 2012·Stem Cells·Shiva BamezaiChristian Buske
Apr 24, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kang YuDeborah N Burshtyn
Jun 22, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter ParhamLisbeth A Guethlein
Nov 19, 2011·Nature Reviews. Genetics·Manel Esteller
Aug 19, 2015·Immunological Reviews·Angela R ManserMarkus Uhrberg
Jan 13, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xue ZhangHui Zhang
Sep 28, 2017·Immunology·Suwit ChaisriChanvit Leelayuwat
Aug 11, 2019·Molecular Cancer·Yongmei LiuWenhua Xu
Mar 25, 2020·International Journal of Molecular Sciences·Gleyce Fonseca CabralÂndrea Ribeiro-Dos-Santos
Aug 8, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cheng-Ying WuFrank Cichocki
Aug 29, 2013·Biochemistry. Biokhimii︠a︡·E Y YakushevM S Klenov
Nov 5, 2019·Trends in Immunology·Youdiil OphinniNicholas F Parrish
Mar 24, 2021·Stem Cell Research & Therapy·Faroogh MarofiFarhad Motavalli Khiavi
Nov 2, 2021·Bioengineered·Pooneh MokarramHassan Ashktorab

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