Cutting edge: Membrane nanotubes in vivo: a feature of MHC class II+ cells in the mouse cornea.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Holly R ChinneryP G McMenamin

Abstract

Membrane nanotubes are a recently discovered form of cellular protrusion between two or more cells whose functions include cell communication, environmental sampling, and protein transfer. Although clearly demonstrated in vitro, evidence of the existence of membrane nanotubes in mammalian tissues in vivo has until now been lacking. Confocal microscopy of whole-mount corneas from wild-type, enhanced GFP chimeric mice, and Cx3cr1(gfp) transgenic mice revealed long (>300 microm) and fine (<0.8 microm diameter) membrane nanotube-like structures on bone marrow-derived MHC class II(+) cells in the corneal stroma, some of which formed distinct intercellular bridges between these putative dendritic cells. The frequency of these nanotubes was significantly increased in corneas subjected to trauma and LPS, which suggests that nanotubes have an important role in vivo in cell-cell communication between widely spaced dendritic cells during inflammation. Identification of these novel cellular processes in the mammalian cornea provides the first evidence of membrane nanotubes in vivo.

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Citations

Nov 6, 2008·Clinical & Experimental Ophthalmology·Paul G McMenamin
May 28, 2009·Prion·Karine Gousset, Chiara Zurzolo
Feb 19, 2010·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Johan HurtigBjörn Onfelt
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Oct 23, 2009·Annals of the New York Academy of Sciences·Amin Rustom
Mar 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Anne ChauveauDaniel M Davis
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Sep 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Xiang WangHans-Hermann Gerdes
Nov 5, 2013·Physiology·Robert S Rogers, Jahar Bhattacharya
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Jun 5, 2014·Cell Communication & Adhesion·Gerardo Arrevillaga-BoniVianney Ortiz-Navarrete
Jun 2, 2015·Frontiers in Physiology·Richard H W Funk
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