Cutting Edge: MicroRNA-223 Regulates Myeloid Dendritic Cell-Driven Th17 Responses in Experimental Autoimmune Encephalomyelitis

The Journal of Immunology : Official Journal of the American Association of Immunologists
Igal IferganStephen D Miller

Abstract

Myeloid cells play a crucial role in the induction and sustained inflammation in neuroinflammatory disorders, such as multiple sclerosis. miR-223, a myeloid cell-specific microRNA, is one of the most upregulated microRNAs in multiple sclerosis patients. We demonstrate that miR-223-knockout mice display significantly reduced active and adoptive-transfer experimental autoimmune encephalomyelitis that is characterized by reduced numbers of myeloid dendritic cells (mDCs) and Th17 cells in the CNS. Knockout mDCs have increased PD-L1 and decreased IL-1β, IL-6, and IL-23 expression, as well as a reduced capacity to drive Th17, but not Th1, cell differentiation. Thus, miR-223 controls mDC-induced activation of pathologic Th17 responses during autoimmune inflammation.

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Citations

Jan 18, 2017·Proceedings of the National Academy of Sciences of the United States of America·William Bracamonte-BaranWilliam J Burlingham
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Jan 29, 2021·Multiple Sclerosis International·Justyna Basak, Ireneusz Majsterek
Oct 31, 2020·Frontiers in Immunology·Igal Ifergan, Stephen D Miller

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