PMID: 15240657Jul 9, 2004Paper

Cutting edge: selective requirement for the Wiskott-Aldrich syndrome protein in cytokine, but not chemokine, secretion by CD4+ T cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
Vanessa Morales-TiradoDeborah J Fowell

Abstract

The mechanism of cytokine secretion is not well understood, but cytokines appear to be synthesized and released in a polarized fashion toward an Ag-specific target cell. In this study, we demonstrate that the Wiskott-Aldrich syndrome protein (WASp) is an essential component of the cytokine secretory pathway in CD4(+) T cells. Murine WASp-deficient CD4(+) T cells fail to polarize cytokines toward a target and show an unexpected and striking block in cytokine secretion. In contrast, chemokine secretion and trafficking of plasma membrane proteins, transported via the constitutive secretory pathway, are unaffected by the lack of WASp. These results suggest that CD4(+) T cell cytokines require a specialized, WASp-dependent pathway for cellular traffic and/or vesicle release that is distinct from that required for chemokine release. We propose that the use of different secretory pathways for cytokines and chemokines enables CD4(+) T cell activity to be further fine-tuned to serve specialized effector functions.

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Citations

Mar 18, 2005·Annual Review of Immunology·Leslie J BergPamela L Schwartzberg
Sep 19, 2008·Nature Immunology·Morgan HuseMark M Davis
Feb 3, 2009·Immunologic Research·Dorothy K SojkaDeborah J Fowell
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Nov 17, 2009·Immunological Reviews·Jinyi ZhangKatherine A Siminovitch
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Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sara TrifariLoïc Dupré
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Feb 25, 2015·Frontiers in Immunology·Vinicius Cotta-de-AlmeidaZilton Vasconcelos
Jan 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Karen BadourKatherine A Siminovitch
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Nov 17, 2020·Frontiers in Cell and Developmental Biology·Marta MastrogiovanniVincenzo Di Bartolo
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Oct 27, 2007·Trends in Immunology·Clare Jolly, Quentin J Sattentau
Nov 12, 2021·Cell and Tissue Research·Wafaa MahmoudWolfgang Kummer

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