Cutting edge: the minor histocompatibility antigen H60 peptide interacts with both H-2Kb and NKG2D

The Journal of Immunology : Official Journal of the American Association of Immunologists
Adelheid CerwenkaLewis L Lanier

Abstract

Minor histocompatibility Ags elicit cell-mediated immune responses and graft rejection in individuals receiving MHC-matched tissues. H60 represents a dominant Ag that elicits a strong CTL response in C57BL/6 mice immunized against BALB.B. An 8-aa peptide in the H60 protein is presented by H-2K(b) and this is recognized by the TCR as an alloantigen. The intact H60 glycoprotein is a ligand for the costimulatory NKG2D receptor that is expressed by activated CD8(+) T cells. Thus, H60 may provide both an allogeneic peptide and its own costimulation. We show that mutation of an H-2K(b)-binding anchor residue in the H60 peptide completely abrogates binding of H60 glycoprotein to NKG2D and a synthetic H60 peptide partially blocks the binding of NKG2D to its ligand. Ligands of the human NKG2D receptor are remarkably polymorphic, suggesting that these may also serve as minor histocompatibility Ags.

References

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Mar 20, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L M MendozaN Shastri
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Sep 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·A CerwenkaL L Lanier

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Citations

Jul 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·He ZhouRalph A Reisfeld
Mar 29, 2011·Immunology·Deepak YadavJack D Bui
Feb 19, 2013·Annals of the Rheumatic Diseases·Christian DejacoMichael Schirmer
Aug 19, 2009·Immunogenetics·Amornrat V RomphrukChanvit Leelayuwat
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Akio TakadaMasanori Kasahara
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jichun ChenNeal S Young
Jan 21, 2004·Journal of Molecular Recognition : JMR·Rebecca L Rich, David G Myszka
Feb 9, 2019·Expert Opinion on Therapeutic Targets·Mariya Lazarova, Alexander Steinle
May 27, 2004·The American Journal of Pathology·Philip B SugermanMarcel R M van den Brink
Apr 23, 2005·Seminars in Hematology·Katharine C Hsu, Bo Dupont

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