Cutting Edge: The RIG-I Ligand 3pRNA Potently Improves CTL Cross-Priming and Facilitates Antiviral Vaccination

The Journal of Immunology : Official Journal of the American Association of Immunologists
Katharina HochheiserChristian Kurts

Abstract

Protective immunity against intracellular pathogens involves the induction of robust CTL responses. Vaccination with protein Ags establishes such responses only when combined with immune-stimulatory adjuvants. In this study, we compared different adjuvants and identified triphosphate RNA (3pRNA) as especially effective at inducing CTL responses. 3pRNA sensing required IPS-1/MAVS signaling and induced type I IFN in plasmacytoid dendritic cells and macrophages, with the latter being more important for the adjuvant effect. Type I IFN acted on CD11c(+) cells, especially on CD8α(+) Batf3-dependent dendritic cells. Vaccination with OVA in combination with 3pRNA protected mice from a subsequent OVA-encoding adenovirus infection in a CD8(+) cell-dependent manner and more efficiently than other adjuvants. In summary, 3pRNA is a superior adjuvant for CTL activation and might be useful to facilitate antiviral immunization strategies.

References

Mar 1, 1997·Journal of Virology·S HardyM L Phipps
Dec 20, 2000·The Journal of Experimental Medicine·J M den HaanM J Bevan
Apr 19, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sandip K DattaEyal Raz
Sep 23, 2003·Nature Immunology·Agnes Le BonDavid F Tough
Nov 18, 2004·Immunological Reviews·Christian BogdanUlrike Schleicher
Nov 19, 2004·Nature Immunology·Marco ColonnaYong-Jun Liu
Jun 25, 2005·Chemical Immunology and Allergy·Hiroaki Hemmi, Shizuo Akira
Jul 26, 2005·Immunity·Hiroki KatoShizuo Akira
Aug 30, 2005·Nature Immunology·Taro KawaiShizuo Akira
Feb 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Agnes Le BonDavid F Tough
Apr 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Agnes Le BonDavid F Tough
Oct 14, 2006·Science·Veit HornungGunther Hartmann
Nov 28, 2007·Annual Review of Pathology·Kenneth L Rock, Hajime Kono
Dec 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Stefanie ScheuRichard M Locksley
Jan 9, 2009·European Journal of Immunology·Isis Ludwig-PortugallChristian Kurts
Apr 8, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dirk StabenowPercy A Knolle
Sep 21, 2011·The Journal of Experimental Medicine·Mark S DiamondRobert D Schreiber
Sep 21, 2012·Nature·Roxane TussiwandKenneth M Murphy
Feb 16, 2013·Journal of the American Society of Nephrology : JASN·Catherine GottschalkChristian Kurts
Jan 18, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel R EngelChristian Kurts

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Citations

Jan 12, 2017·Trends in Immunology·Alessandra ZeviniJohn Hiscott
Jun 13, 2017·Human Vaccines & Immunotherapeutics·John J SuschakConnie S Schmaljohn
Mar 1, 2018·Annual Review of Immunology·J Magarian Blander
Nov 30, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marika EndersChristian Kurts
Mar 2, 2018·Science Advances·Melissa M LinehanAnna M Pyle
Oct 26, 2018·Frontiers in Physiology·Lesca M HoldtDaniel Teupser
May 3, 2020·Journal of Neuroinflammation·M Brittany JohnsonIan Marriott
Jan 18, 2017·Frontiers in Immunology·Yiliu LiuRongtuan Lin
Mar 24, 2020·Nature Reviews. Immunology·Jan Rehwinkel, Michaela U Gack
Sep 14, 2019·Molecular Cancer Therapeutics·Mike W HelmsLars M König
Jul 3, 2021·Drug Discovery Today·Dalinda EusébioÂngela Sousa

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