Cu/Zn-SOD in human pancreatic tissue and pancreatic juice

International Journal of Pancreatology : Official Journal of the International Association of Pancreatology
D H HausmannJ Emmrich

Abstract

Cu/Zn-SOD is present in pancreatic juice and tissue. Immunohistochemical studies reveal a localization of this enzyme in islet, duct, and centroacinar cells, but to a much lower extent in pancreatic acinar cells. It is generally accepted that oxygen radicals are involved in the pathogenesis of acute and chronic pancreatitis. An imbalance of radical-generating and radical-scavenging processes is thought to lead to the damage of pancreatic acinar cells that initiate the autodigestion of the whole organ. We investigated the distribution pattern of the cytosolic radical-scavenging enzyme, copper/zinc-superoxide dismutase (Cu/Zn-SOD), in pancreatic juice and tissue. In patients with chronic pancreatitis or pancreatic malignancies, Cu-Zn-SOD was quantitated in different fractions of pancreatic juice by means of an enzyme immunoassay using two Cu/Zn-SOD-specific monoclonal antibodies. Cryostat or paraffin sections of pancreatic tissue were analyzed by immunohistochemical techniques. We found this enzyme to be present in the first secretin-triggered fraction of endoscopically obtained pancreatic juice in concentrations similar to serum. In contrast, after cholecystokinin stimulation, only low levels could be found in pancreatic juice, ...Continue Reading

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Citations

Jul 17, 2020·International Journal of Molecular Sciences·Maria C Linder
Aug 19, 2008·Biological Trace Element Research·Satish Kumar Taneja, Reshu Mandal
Jan 7, 2003·The Journal of Biological Chemistry·Vytautas P BindokasLouis H Philipson
Sep 10, 2011·Antioxidants & Redox Signaling·Rakesh Kumar Tandon, Pramod Kumar Garg

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