CX-4945: the protein kinase CK2 inhibitor and anti-cancer drug shows anti-fungal activity

Molecular and Cellular Biochemistry
Maciej MasłykKonrad Kubiński

Abstract

CX-4945 is a selective inhibitor of protein kinase CK2 exhibiting clinical significance. Its antitumor properties arise from the abrogation of CK2-mediated pro-survival cellular pathways. The presented data reveal the influence of CX-4945 on the growth of yeast cells showing variable potency against Saccharomyces cerevisiae deletion strains with different contents of CK2 subunits. The catalytic subunit CK2α appears to sensitize yeast to the CX-4945 action. Moreover, the compound suppresses hyphal growth and cell adhesion of Candida albicans, thereby abolishing some hallmarks of invasiveness of the pathogen. It is known that cancer patients are more prone to fungal infections. Our data unveil the dual-activity of CX-4945; when used in anti-cancer therapy, it may simultaneously prevent cancer-associated candidiasis.

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Citations

Feb 15, 2018·International Journal of Molecular Sciences·Nancy Martinez-MontielRebeca Martinez-Contreras
Jun 23, 2020·Future Medicinal Chemistry·Harlei MartinTrinidad Velasco-Torrijos
Apr 16, 2020·Journal of Animal Science and Biotechnology·Xiayan ShiYangBo Xiong
May 22, 2020·ACS Medicinal Chemistry Letters·Loganathan RangasamyBeatriz de Pascual-Teresa

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