CXCL-10 and Interleukin-6 are reliable serum markers for vitiligo activity: A multicenter cross-sectional study

Pigment Cell & Melanoma Research
Marwa AbdallahEgyptian Vitiligo Group

Abstract

This cross-sectional multicenter study aimed to evaluate serum CXCL-10, as an activity marker for vitiligo, and compare it with other putative serum and tissue markers. Serum CXCL-10 was compared to interferon gamma (IFN-γ), interleukin 6 (IL-6), and IL-17 using ELISA in 55 non-segmental vitiligo patients (30 active and 25 stable) and 30 healthy controls. Marginal skin biopsy was taken for immunohistochemical evaluation of CD8+T cells and CXCL-10+ve cells. Serum levels of CXCL-10, IL-17, and IL-6 were elevated in all vitiligo patients compared to controls (p < .05). All investigated serum markers were higher in active versus stable vitiligo. Tissue expression of CXCL-10+ve cells and CD8+ve T cells was stronger in vitiligo patients compared to controls, and tissue CXCL-10+ve cell expression was stronger in active versus stable cases. Positive correlations were noted between the different serum and tissue markers. CXCL-10 was the most specific, whereas IL-6 was the most sensitive serum marker to distinguish active from stable disease.

References

Jul 10, 2004·Journal of the American Academy of Dermatology·Pearl E GrimesAllan Metzger
Nov 22, 2008·Journal of the American Academy of Dermatology·Pinar Y BasakVahide B Akkaya
Feb 27, 2009·The Journal of Investigative Dermatology·Jasper G van den BoornRosalie M Luiten
Jan 5, 2011·Clinical and Experimental Dermatology·D A Bassiouny, O Shaker
Oct 11, 2011·Pigment Cell & Melanoma Research·Nanja van GeelLieve Brochez
Mar 16, 2012·Pigment Cell & Melanoma Research·K EzzedineUNKNOWN Vitiligo Global Issue Consensus Conference Panelists
Apr 4, 2012·Indian Journal of Dermatology·Suman SinghS S Pandey
Jun 15, 2012·The Journal of Investigative Dermatology·Siavash ToosiPrashiela Manga
May 18, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Manoj Kumar TembhreSomesh Gupta
Jun 20, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Mitesh DwivediRasheedunnisa Begum
Sep 12, 2013·Journal of Cutaneous and Aesthetic Surgery·Kanika Sahni, Davinder Parsad
Nov 6, 2013·Autoimmunity Reviews·Alessandro AntonelliPoupak Fallahi
Jan 21, 2014·Pigment Cell & Melanoma Research·Antoine BertolottiJulien Seneschal
Feb 14, 2014·Science Translational Medicine·Mehdi RashighiJohn E Harris
Feb 18, 2014·International Journal of Dermatology·Marwa AbdallahRiham Galal
Aug 26, 2014·International Journal of Inflammation·José Francisco Zambrano-ZaragozaNorberto Vibanco-Pérez
Oct 7, 2015·Autoimmune Diseases·Yaswanth AlaParveen Jahan
Mar 6, 2017·Journal of the American Academy of Dermatology·James P StrassnerJohn E Harris

❮ Previous
Next ❯

Citations

Jun 12, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·C B Bunker, J Manson
May 8, 2019·Pigment Cell & Melanoma Research·Reinhart SpeeckaertNanja van Geel
Jan 3, 2020·The Australasian Journal of Dermatology·Prakash Acharya, Mahesh Mathur
Feb 6, 2020·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Hoda M RasheedNesrin S Elkhouly
Oct 28, 2019·Frontiers in Immunology·Michael D HowellPaul A Smith
Apr 9, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Guangming ZhaoZhiqi Song
Dec 6, 2020·Pigment Cell & Melanoma Research·Julien SeneschalMauro Picardo
Jan 7, 2021·The Journal of Dermatology·Christina Bergqvist, Khaled Ezzedine
Jul 16, 2021·Photodermatology, Photoimmunology & Photomedicine·Fuquan LinAi-E Xu
Aug 11, 2021·Pharmaceutics·Paul SmithSwamy Yeleswaram
Aug 28, 2021·International Journal of Molecular Sciences·Andrea D'ArinoPaolo Iacovelli
Mar 11, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Christina Bergqvist, Khaled Ezzedine
Nov 16, 2021·Pigment Cell & Melanoma Research·Xinya XuLeihong Flora Xiang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.