CXCL1 regulation of oligodendrocyte progenitor cell migration is independent of calcium signaling

Experimental Neurology
Parvez VoraEmma E Frost

Abstract

Cell migration is an indispensable aspect of tissue patterning during embryonic development. Oligodendrocytes, the myelinating cells of the central nervous system, migrate significantly during development of the brain. Several growth factors have been identified as being critical regulators of oligodendrocyte progenitor migration, including platelet derived growth factor-A (PDGFA), and fibroblast growth factor-2 (FGF2). Further, the chemokine CXCL1 has been shown to play a critical role in regulating the dispersal of oligodendrocyte progenitors during development, although the mechanisms underlying this regulation are unknown. Previous studies have also shown that calcium flux is required for oligodendrocyte progenitor migration. CXCL1 induces calcium flux in cells; therefore, we hypothesized that CXCL1 inhibition of oligodendrocyte progenitor migration is regulated via changes in intracellular calcium flux. The current study shows that CXCL1 inhibition of oligodendrocyte progenitor migration is independent of calcium signaling. Further, we show that CXCL1 inhibition of oligodendrocyte progenitor migration is specific to PDGFA induced migration. Finally, we show that CXCL1 inhibition of oligodendrocyte progenitor migration is i...Continue Reading

References

Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J E Bottenstein, G H Sato
Nov 1, 1990·Journal of Neuroscience Research·R C ArmstrongM E Dubois-Dalcq
Nov 15, 1988·The Journal of Comparative Neurology·S M LeVine, J E Goldman
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·O MeucciR J Miller
Mar 10, 1999·Methods : a Companion to Methods in Enzymology·R C Armstrong
Nov 11, 1999·Current Biology : CB·E E FrostC ffrench-Constant
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·R ChittajalluV Gallo
May 10, 2002·Trends in Neurosciences·Hui-Hsin Tsai, Robert H Miller
Jun 21, 2002·Trends in Cell Biology·Philip J S Stork, John M Schmitt
Jul 27, 2002·Annual Review of Cell and Developmental Biology·M Freeman, J B Gurdon
Sep 17, 2002·Biological & Pharmaceutical Bulletin·Futoshi ShibataHideo Nakagawa
Jan 18, 2003·Journal of Neurobiology·Emma E FrostRegina C Armstrong
Oct 3, 2003·Current Biology : CB·Rick Horwitz, Donna Webb
Mar 17, 2004·Current Opinion in Neurology·Raphael Schiffmann, Marjo S van der Knaap
Dec 4, 2004·Glia·Igor Jakovcevski, Nada Zecevic
Dec 14, 2004·Biochimica Et Biophysica Acta·Michael J Berridge
Mar 19, 2005·Brain : a Journal of Neurology·Kakuri M OmariCedric S Raine
May 3, 2005·Cytokine & Growth Factor Reviews·V P EswarakumarJ Schlessinger
May 18, 2005·Biochemical and Biophysical Research Communications·Ru Liu-BryanDavid M Rose
Aug 9, 2005·Glia·Kakuri M OmariCedric S Raine
Jan 4, 2006·Archives of General Psychiatry·Timothy R PeirceMichael C O'Donovan
Nov 7, 2007·Journal of Neuropathology and Experimental Neurology·Adam C VanaRegina C Armstrong
Dec 7, 2007·Cardiovascular Research·Masahiro MurakamiMichael Simons

❮ Previous
Next ❯

Citations

Jan 16, 2016·Cellular and Molecular Life Sciences : CMLS·John BiancoAnne des Rieux
May 7, 2016·Experimental Neurology·Evan Z GoldsteinDana M McTigue
Sep 9, 2016·Frontiers in Behavioral Neuroscience·Caroline C de OliveiraRaquel C R Martinez
Jan 17, 2019·Journal of Molecular Neuroscience : MN·Juhi SinghPrakash P Pillai
Jul 2, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laila A Al-AlwanQutayba Hamid
Jun 30, 2021·Molecular and Cellular Neurosciences·Viridiana Vargas-CastroBertha Alicia Leon-Chavez
Aug 7, 2021·Biomolecules·Ilias Kalafatakis, Domna Karagogeos
Oct 14, 2021·Developmental Neurobiology·Wenlong Xia, Stephen P J Fancy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.