CXCL10 gene promoter polymorphism -1447A>G correlates with plasma CXCL10 levels and is associated with male susceptibility to cerebral malaria

PloS One
Nana O WilsonJonathan K Stiles

Abstract

The risk factors for cerebral malaria (CM) and the wide variation in clinical manifestations of malaria are poorly understood. Recent studies indicate that interferon gamma inducible chemokine, CXCL10, is a strong predictor of both human and experimental cerebral malaria. Increased plasma and cerebrospinal fluid levels of CXCL10 were tightly associated with fatal CM in Indian and Ghanaian patients. In the present study, we hypothesized that in a subset of malaria patients, CM susceptibility is associated with variation in CXCL10 expression. We determined whether polymorphisms in the CXCL10 gene promoter region played a role in the clinical status of malaria patients and addressed the genetic basis of CXCL10 expression during malaria infection. Following extensive bioinformatics analyses, two reported single nucleotide polymorphisms in the CXCL10 promoter (-135G>A [rs56061981] and -1447A>G [rs4508917]) were identified among 66 CM and 69 non-CM Indian patients using PCR-restriction fragment length polymorphism assay. Individuals with the -1447(A/G) genotype were susceptible to CM (adjusted odds ratio [AOR] = 2.60, 95% CI = 1.51-5.85, p = 0.021). In addition, individuals with the -1447(A/G) genotype had significantly higher plasma...Continue Reading

References

Oct 1, 1987·The Journal of Experimental Medicine·A D Luster, J V Ravetch
May 25, 1995·The New England Journal of Medicine·K MarshN Peshu
Jun 24, 1994·Science·L H MillerG Milon
Nov 1, 1996·The Journal of Infectious Diseases·M B van HensbroekB Greenwood
Oct 1, 1996·International Journal for Parasitology·M Zuk, K A McKean
Sep 4, 1999·Neuropathology and Applied Neurobiology·H BrownG Turner
Mar 4, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·P A HoldingK Marsh
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Aug 17, 2005·Journal of Virology·Robyn S KleinMichael S Diamond
Nov 2, 2005·PLoS Medicine·Margaret J MackinnonThomas N Williams
Jun 22, 2006·Neuroscience Letters·Eliana VenturelliElio Scarpini
Oct 7, 2006·Seminars in Immunology·Susana CampinoAlain Dessein
Jan 26, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·D GalimbertiE Scarpini
Mar 17, 2007·Annals of Tropical Medicine and Parasitology·S K MishraD N Mohapatra
Jan 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jenny MiuNicholas H Hunt
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bo ZhangRobyn S Klein
Mar 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Gabriele S V CampanellaAndrew D Luster
Jul 24, 2008·FEMS Immunology and Medical Microbiology·Yumi ShirakiShigaku Ikeda
Aug 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Erin E McCandlessRobyn S Klein
Sep 25, 2008·The American Naturalist·A P MøllerJ Erritzøe
Jun 16, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Nelson Leung-Sang TangChiu Yeung Chan
Nov 4, 2009·Journal of Postgraduate Medicine·V P Gautam
Mar 17, 2010·The American Journal of Pathology·Blanche Ka Ki LoKevin John McElwee
Apr 22, 2011·Disease Markers·Nana O WilsonJonathan K Stiles
Sep 23, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A TraversoE Pozio
Mar 1, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Paola Romagnani, Clara Crescioli
Jun 2, 2012·The Pediatric Infectious Disease Journal·Smiti BihariLuis E Cuevas
Nov 13, 2012·PloS One·Alphaxard ManjuranoChristopher Drakeley
Oct 22, 2013·Archives of Disease in Childhood·Pia Hardelid, Ruth Gilbert
Jul 30, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kayhan ErturkSezai Vatansever

❮ Previous
Next ❯

Citations

Jul 8, 2014·PloS One·Susanna EspositoNicola Principi
Dec 17, 2014·Cytokine & Growth Factor Reviews·Katrien Van RaemdonckSofie Struyf
Mar 17, 2015·Seminars in Immunopathology·Shanshan Wu HowlandLaurent Rénia
Sep 2, 2014·Frontiers in Cellular and Infection Microbiology·Nicholas H HuntGeorges E R Grau
Dec 30, 2017·Molecular Genetics and Genomics : MGG·Yan WangWenju Lu
Jan 7, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Daniel Pineda-TenorSalvador Resino
Mar 7, 2017·Frontiers in Cellular and Infection Microbiology·João L Silva-FilhoAna A S Pinheiro
Jul 30, 2017·Clinical and Translational Medicine·María Ángeles Jiménez-SousaSalvador Resino
Jan 12, 2021·Frontiers in Immunology·Keri Oxendine HarpAdel Driss
Jan 22, 2021·Pathogens and Disease·Mariana Cavalheiro MagriFátima Mitiko Tengan
Nov 23, 2021·Frontiers in Cellular and Infection Microbiology·Lena FeigeLaurent Dacheux

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
PCR
ELISA

Software Mentioned

GeneView
Quanto
SAS
SigmaPlot
Haploview
GraphPad Prism
SigmaStat

Related Concepts

Related Feeds

Alzheimer's Disease: Genetics

Alzheimer's disease is a neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations with this feed.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Blood Brain Barrier & Cytokines

Some cytokines are able to cross the blood brain barrier through transport systems and enter the cerebrospinal fluid and interstitial fluid spaces. Here is the latest research on cytokines crossing the blood brain barrier and how this can affect tissues within the CNS.

Related Papers

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
Giovanni CorsoFranco Roviello
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
I SuzukiY Kawakami
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Guohong DengFuchu He
© 2021 Meta ULC. All rights reserved