CXCL12/CXCR4 Axis Improves Migration of Neuroblasts Along Corpus Callosum by Stimulating MMP-2 Secretion After Traumatic Brain Injury in Rats.

Neurochemical Research
Weifeng MaoGuohua Jin

Abstract

To investigate the effect of CXCL12 on migration of neural precursor cells after traumatic brain injury (TBI). We randomly divided 48 rats into four groups: (1) the sham group, rats were performed craniotomy only, (2) the control group, saline were injected into the ipsilateral cortex after TBI, (3) the CXCL12 group, CXCL12 were injected into the ipsilateral cortex after TBI, and (4) the CXCL12 + AMD3100 group, CXCL12 and AMD3100 were mixed together and injected into the ipsilateral cortex after TBI. At 7 days after TBI, the brain tissues were subjected to immunofluorescent double-labeled staining with the antibodies of CXCR4/DCX, MMP-2/DCX, MMP-2/GFAP, MMP-2/NeuN. Western blot assay was used to measure the protein levels of MMP-2. Compared with the control group, the number of CXCR4/DCX and MMP-2 positive cells around the injured corpus callosum area were significantly increased in the CXCL12 treatment group. The area occupied by these cells expanded and the shape changed from chain distribution to radial. CXCL12 + AMD3100 treatment significantly decreased the number and distribution area of CXCR4/DCX and MMP-2 positive cells compared with the CXCL12 treatment and control group. The DCX positive cells could not form chain or r...Continue Reading

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Citations

Oct 13, 2017·International Journal of Clinical Oncology·Alireza NazariGholamhossein Hassanshahi
Feb 8, 2018·Biomedical Materials·Kassondra Hickey, Sarah E Stabenfeldt
Jan 19, 2018·Journal of Neuroscience Research·Naijil George, Herbert M Geller
May 19, 2019·Cellular and Molecular Life Sciences : CMLS·Natanael ZarcoHugo Guerrero-Cázares
Dec 29, 2020·Frontiers in Pharmacology·Yi ShiJianzhong Shen
Apr 4, 2021·International Journal of Molecular Sciences·Mehdi EshraghiSaeid Ghavami

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