CXCL12/CXCR4 axis in the microenvironment of solid tumors: A critical mediator of metastasis

Life Sciences
Keywan Mortezaee

Abstract

Tumors are dynamic tissue masses, so requiring continuous exposure to the host cells, nurturing them into pave a path for tumor growth and metastasis. C-X-C chemokine ligand 12 (CXCL12)/C-X-C chemokine receptor type 4 (CXCR4) is the key signaling for such aim. Gathering knowledge about the activity within this axis would deepen our insight into the utmost importance this signaling taken to attract and cross-connect multiple cells within the tumor microenvironment (TME) aiming for tumor progression and metastasis. The concept behind this review is to underscore the multi-tasking roles taken by CXCL12/CXCR4 signaling in tumor metastasis, and to also suggest some strategies to target the activities within this axis.

Citations

Apr 9, 2020·Vaccines·Stefania ScalaElena Monica Borroni
Jun 7, 2020·International Journal of Molecular Sciences·Milad AshrafizadehGautam Sethi
Oct 1, 2020·International Journal of Molecular Sciences·Bilash ChatterjeeAmit Kumar Srivastava
Aug 14, 2020·Cancers·Alessandra CaligiuriAlessandra Gentilini
Nov 26, 2020·Cell Biology International·Keywan Mortezaee
Jan 5, 2021·Medical Oncology·Jamal Majidpoor, Keywan Mortezaee
Dec 15, 2020·European Journal of Pharmacology·Milad AshrafizadehMasoud Najafi
Dec 3, 2020·Critical Reviews in Oncology/hematology·Keywan Mortezaee, Masoud Najafi
Jan 26, 2021·Journal of Biochemical and Molecular Toxicology·Keywan Mortezaee
Feb 14, 2021·European Journal of Pharmacology·Simona DanieleLuciana Marinelli
Feb 7, 2021·Journal of Clinical Medicine·Andres Garcia-SampedroPilar Acedo
Jan 9, 2021·Frontiers in Immunology·Shahid HussainRamesh K Ganju
Mar 12, 2021·Journal of Clinical Pathology·Natalia RusetskaMagdalena Kowalewska
Mar 18, 2021·Future Oncology·Keywan Mortezaee
Jul 20, 2020·International Immunopharmacology·Milad AshrafizadehMasoud Najafi
Apr 10, 2021·Cellular Oncology (Dordrecht)·Jamal Majidpoor, Keywan Mortezaee
Apr 12, 2021·Immunity·Aleksandra J OzgaAndrew D Luster
May 1, 2021·International Journal of Molecular Sciences·Anna Li SantiPia Ragno
May 1, 2021·International Journal of Molecular Sciences·Colin F DavenportDoan Duy Hai Tran
Jun 2, 2021·Biochemical Society Transactions·Wing Yee Lai, Anja Mueller
Jul 14, 2021·The Journal of Clinical Investigation·Xueliang GaoHaizhen Wang

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