CXCL13 promotes isotype-switched B cell accumulation to the central nervous system during viral encephalomyelitis

Brain, Behavior, and Immunity
Timothy W PharesCornelia C Bergmann

Abstract

Elevated CXCL13 within the central nervous system (CNS) correlates with humoral responses in several neuroinflammatory diseases, yet its role is controversial. During coronavirus encephalomyelitis CXCL13 deficiency impaired CNS accumulation of memory B cells and antibody-secreting cells (ASC) but not naïve/early-activated B cells. However, despite diminished germinal center B cells and follicular helper T cells in draining lymph nodes, ASC in bone marrow and antiviral serum antibody were intact in the absence of CXCL13. The data demonstrate that CXCL13 is not essential in mounting effective peripheral humoral responses, but specifically promotes CNS accumulation of differentiated B cells.

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Citations

Sep 27, 2016·The Journal of General Virology·Victoria K Baxter, Diane E Griffin
Nov 20, 2018·The Journal of General Virology·Kimberly L W SchultzDiane E Griffin
Feb 9, 2021·Reviews in the Neurosciences·Dian Eurike Septyaningtrias, Rina Susilowati
Nov 24, 2020·Frontiers in Neurology·Rittika ChunderStefanie Kuerten
Jan 7, 2021·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Krista D DiSanoAndrew R Pachner

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Methods Mentioned

BETA
fluorescence activated cell sorting
FACS
PCR
ELISA
FCS
flow cytometry

Software Mentioned

FlowJo
GraphPad Prism

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