CXCL9 chemokine level is associated with spontaneous clearance and sustained virological response in Egyptian Chronic Hepatitis C patients receiving direct acting antivirals.

Human Antibodies
Ashraf A TabllYasmine S El Abd

Abstract

Chronic Hepatitis C virus (HCV) infection is associated with progressive liver inflammation which in turn leads to cirrhosis and finally causes hepatocellular carcinoma (HCC). By different escape mechanisms, the virus succeeds to evade the innate and acquired immune responses to establish chronic infection. This study aimed to evaluate the level of chemokine CXCL9 and its correlation with some biochemical parameters in different subjects of HCV patients. A total of 83 persons participated in this study including healthy subjects without both HCV antibodies and HCV RNA (22.9%), HCV treated responders accomplished SVR post treatment, with HCV antibodies and absence of HCV RNA (24.1%), spontaneous or natural clearance patients, with positive HCV antibodies and negative HCV RNA without treatment (26.5%) and chronic HCV-patients, with both positive HCV antibodies and HCV RNA with no treatment (26.5%). HCV RNA was quantitated by real time PCR and serum CXCL9 level was measured by ELISA commercial kit pre-coated with human MIG/CXCL9 antibody. Assessment of biochemical and hematological parameters was carried out. Data showed that, the level of CXCL9 was significantly increased in chronic individuals (627.1 pg/ml) (P< 0.001) than spont...Continue Reading

References

Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·P FarciR H Purcell
Jan 4, 2003·Gastroenterology·Marc G GhanyJay H Hoofnagle
Jun 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·C LogvinoffJ A McKeating
Apr 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hongjin HuangRamsey C Cheung
Jul 10, 2009·The Journal of Clinical Investigation·Barbara Rehermann
Jan 25, 2011·Journal of Hepatology·Marija ZeremskiAndrew H Talal
Apr 28, 2012·Gastroenterology·Hashem B El-Serag
Jun 6, 2012·European Journal of Gastroenterology & Hepatology·Jun Liong ChinP Aiden McCormick
Sep 13, 2012·Experimental and Therapeutic Medicine·Kazuhiro KotohMunechika Enjoji
Nov 23, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Khayriyyah Mohd HanafiahSteven T Wiersma
Jan 3, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Homie RazaviRitesh Kumar
May 15, 2013·World Journal of Hepatology·Tatsuo KandaOsamu Yokosuka
Jul 12, 2013·International Journal of Nephrology and Renovascular Disease·Chadi SaifanSuzanne El-Sayegh
Aug 6, 2013·Journal of Viral Hepatitis·G S CookeN Ford
Sep 8, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Susanne JohanssonJeroen Aerssens
Apr 30, 2017·The Journal of Investigative Dermatology·Jack C O'BrienHeidi T Jacobe
Jul 30, 2017·Clinical and Translational Medicine·María Ángeles Jiménez-SousaSalvador Resino
Apr 5, 2019·Nature Communications·Chao ZhangHong Tang
Sep 19, 2019·World Journal of Clinical Cases·Mortada Hf El-ShabrawiHisham R El-Khayat

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.