CXCR3.1 and CXCR3.2 Differentially Contribute to Macrophage Polarization in Teleost Fish

The Journal of Immunology : Official Journal of the American Association of Immunologists
Xin-Jiang LuJiong Chen

Abstract

The study of multiple copies of chemokine receptor genes in various teleosts has long appealed to investigators seeking to understand the evolution of the immune system. The CXCR CXCR3 gene has two isoforms, CXCR3.1 and CXCR3.2, which are both expressed in macrophages. The distinct roles of teleost CXCR3s have not been identified previously. In this article, we found that CXCR3.1 and CXCR3.2 differentially contributed to macrophage polarization in the teleosts: ayu (Plecoglossus altivelis), grass carp (Ctenopharyngodon idella), and spotted green pufferfish (Tetraodon nigroviridis). In ayu macrophages, the P. altivelis CXCR3.1 (PaCXCR3.1) gene was constitutively expressed, whereas the P. altivelis CXCR3.2 (PaCXCR3.2) gene was induced postinfection with Escherichia coli Upon E. coli infection, PaCXCR3.1+ and PaCXCR3.2+ macrophages showed an M1 and an M2 phenotype, respectively. CXCL9-11-like proteins mediated M1 and M2 polarization by interacting with the PaCXCR3.1 and PaCXCR3.2 proteins on macrophages, respectively. The transcription factors P. altivelis STAT1 and P. altivelis STAT3 were activated in PaCXCR3.1+ and PaCXCR3.2+ macrophages, respectively. Furthermore, the prognosis of septic ayu adoptively transferred with PaCXCR3....Continue Reading

References

Jul 1, 1997·Developmental and Comparative Immunology·L Bramble, R S Anderson
Nov 6, 2002·The Journal of Biological Chemistry·Ian Clark-LewisPius Loetscher
Mar 29, 2003·Intensive Care Medicine·Mitchell M LevyUNKNOWN International Sepsis Definitions Conference
Mar 25, 2004·Nature Reviews. Immunology·J David Lambeth
Jan 11, 2005·Lancet·Djillali AnnaneJean-Marc Cavaillon
Jun 14, 2005·Molecular Immunology·Puttharat BaoprasertkulZhanjiang Liu
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maaike JoerinkGeert F Wiegertjes
Nov 9, 2007·Developmental and Comparative Immunology·Magdalena ChadzinskaB M Lidy Verburg-van Kemenade
Aug 20, 2008·Nature Immunology·Shannon K BromleyAndrew D Luster
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie BenoitJean-Louis Mege
Sep 10, 2008·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Li-Chen ChenJen-Leih Wu
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francisco J RocaVictoriano Mulero
Jun 26, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tiehui WangChristopher J Secombes
Nov 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ai-Fu LinJian-Zhong Shao
Oct 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Narges AghaallaeiThomas Boehm
Mar 19, 2011·Developmental and Comparative Immunology·Maria ForlenzaGeert F Wiegertjes
Aug 13, 2011·Nature·Bastiaan StarKjetill S Jakobsen
Oct 26, 2011·Nature Reviews. Immunology·Toby Lawrence, Gioacchino Natoli
Mar 2, 2012·The Journal of Clinical Investigation·Antonio Sica, Alberto Mantovani
Jun 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Alicia ArranzChristos Tsatsanis
Sep 15, 2012·Current Biology : CB·Daniel Okin, Ruslan Medzhitov
Dec 21, 2012·The Journal of Experimental Medicine·Xin-Jiang LuLei Xu
Mar 20, 2013·Nature Immunology·J Oriol Sunyer
May 25, 2013·Developmental and Comparative Immunology·Jun ChenJun Zou
May 31, 2013·European Journal of Immunology·Baubak Bajoghli
Nov 19, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Suhee HongTiehui Wang
Apr 10, 2014·The Journal of Clinical Investigation·Yaniv ZoharNathan Karin
Nov 11, 2014·Annual Review of Animal Biosciences·Thomas Boehm, Jeremy B Swann
Dec 3, 2014·Fish & Shellfish Immunology·Jiong ChenChang-Hong Li
Jan 13, 2015·Disease Models & Mechanisms·Vincenzo TorracaAnnemarie H Meijer
Jan 28, 2015·General and Comparative Endocrinology·Jun ZouChris J Secombes
Mar 24, 2015·The Journal of Clinical Investigation·Jun XuHidekazu Tsukamoto
Jul 15, 2015·ELife·Mai Nguyen-ChiFarida Djouad
Jul 26, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elena IzquierdoMaría M Escribese
Jul 27, 2015·Cellular and Molecular Life Sciences : CMLS·Antonio SicaChiara Porta

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Citations

Jan 22, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xin-Jiang LuJiong Chen
Jan 27, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ali VuralJohn H Kehrl
Aug 12, 2020·Scientific Reports·Annelieke S WentzelGeert F Wiegertjes
Nov 13, 2020·Frontiers in Cell and Developmental Biology·Youngjin ParkViswanath Kiron
Nov 26, 2020·Developmental and Comparative Immunology·Frida SommerAnnemarie H Meijer
Jul 15, 2020·Seminars in Cancer Biology·Bo MaJunnian Zheng
Dec 29, 2020·Frontiers in Immunology·Xin-Jiang LuKim Dawn Thompson
Sep 1, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yanqi ZhangJianguo Su
Oct 25, 2021·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Tian-Cheng JinJiong Chen

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