CXCR4-mediated osteosarcoma growth and pulmonary metastasis is suppressed by MicroRNA-613

Cancer Science
Yong ZhuHaitao Long

Abstract

Osteosarcoma is the most common primary bone malignancy. Recently, studies showed chemokine receptor 4 (CXCR4) played a critical role in osteosarcoma. However, the regulation of CXCR4 is not fully understood. microRNAs are short, non-coding RNAs that play an important roles in post-transcriptional regulation of gene expression in a variety of diseases including osteosarcoma. miR-613 is a newly discovered miRNA and has been reported to function as a tumor suppressor in many cancers. In this study, we confirmed that both Stromal Cell-Derived Factor (SDF-1) and CXCR4 could be prognostic markers for osteosarcoma. Meanwhile this study found that SDF-1/CXCR4 pathway regulated osteosarcoma cells proliferation, migration and reduced apoptosis. Besides, we demonstrated that miR-613 was significantly downregulated in osteosarcoma patients. Elevated expression of miR-613 directly suppressed CXCR4 expression and then decreased the proliferation, migration and induced apoptosis of osteosarcoma cells. Moreover, our study found that CXCR4 promoted the development of lung metastases and inhibition of CXCR4 by miR-613 reduced lung metastases. These data indicated that CXCR4 mediated osteosarcoma cell growth and lung metastases and this effect c...Continue Reading

References

Nov 1, 2006·Clinical Orthopaedics and Related Research·Rex C HaydonTong-Chuan He
Dec 12, 2007·Clinical & Experimental Metastasis·Su Young KimLee J Helman
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Mar 6, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Richard Gorlick, Chand Khanna
Mar 10, 2010·Cancer Treatment and Research·Giulia Ottaviani, Norman Jaffe
May 21, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Beverly A Teicher, Simon P Fricker
Sep 15, 2010·Cancer Metastasis Reviews·Xueqing SunJianhua Wang
Feb 22, 2011·Cancer Causes & Control : CCC·Ramandeep S AroraJillian M Birch
Mar 26, 2011·Sarcoma·Sharon A Savage, Lisa Mirabello
Mar 9, 2012·Cancer Immunology, Immunotherapy : CII·Crescenzo D'AlterioStefania Scala
May 3, 2012·Sarcoma·Eisuke KobayashiZhenfeng Duan
Sep 23, 2014·Cell Biochemistry and Biophysics·Ruibo ZhaoBuhua Sun
Oct 8, 2014·Advances in Cancer Research·Samit ChatterjeeSridhar Nimmagadda
Sep 18, 2015·Frontiers in Pediatrics·Valerie B SampsonE Anders Kolb
Oct 30, 2015·Expert Opinion on Pharmacotherapy·Stefano Ferrari, Massimo Serra
Aug 9, 2016·Cancer Cell International·Youguang PuShanbao Cai
Nov 12, 2016·Oncotarget·Sanaz TaromiMeike Burger
Apr 30, 2017·Oncology Letters·Pengzhou GaiLei Jiang
May 6, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Di ZhaoShaowei Luo
May 13, 2017·Experimental & Molecular Medicine·Zhen-Huan JiangZhi-Jun Ge

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Citations

Apr 6, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G M VieraM S Brassesco
Mar 25, 2019·Current Osteoporosis Reports·Eric Hesse, Hanna Taipaleenmäki
Feb 19, 2019·Journal of Cellular and Molecular Medicine·Weixin XieZhanchun Li
Feb 20, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yilong DaiKun Yu
Jan 10, 2019·Frontiers in Immunology·Franziska EckertStephan M Huber
Dec 17, 2020·Cancers·Tomasz M GrzywaPaweł K Włodarski
Dec 27, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jie MeiYan Zhang
Feb 23, 2021·Frontiers in Cell and Developmental Biology·Zucheng LuoJixin Xue
Jul 31, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Ke-Da YangZhi-Jun Zeng

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Methods Mentioned

BETA
surgical resection
biopsy
ELISA
PCR
RNA assay
protein assay
electrophoresis
transfection
xenograft
Flow

Software Mentioned

Quantity One
GraphPad Prism
Targetscan
SPSS

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