CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion

Journal of Molecular Histology
Magda KuciaMariusz Z Ratajczak

Abstract

Chemokines, small pro-inflammatory chemoattractant cytokines, that bind to specific G-protein-coupled seven-span transmembrane receptors present on plasma membranes of target cells are the major regulators of cell trafficking. In addition some chemokines have been reported to modulate cell survival and growth. Moreover, compelling evidence is accumulating that cancer cells may employ several mechanisms involving chemokine-chemokine receptor axes during their metastasis that also regulate the trafficking of normal cells. Of all the chemokines, stromal-derived factor-1 (SDF-1), an alpha-chemokine that binds to G-protein-coupled CXCR4, plays an important and unique role in the regulation of stem/progenitor cell trafficking. First, SDF-1 regulates the trafficking of CXCR4+ haemato/lymphopoietic cells, their homing/retention in major haemato/lymphopoietic organs and accumulation of CXCR4+ immune cells in tissues affected by inflammation. Second, CXCR4 plays an essential role in the trafficking of other tissue/organ specific stem/progenitor cells expressing CXCR4 on their surface, e.g., during embryo/organogenesis and tissue/organ regeneration. Third, since CXCR4 is expressed on several tumour cells, these CXCR4 positive tumour cells...Continue Reading

Citations

Dec 2, 2008·Archivum Immunologiae Et Therapiae Experimentalis·Maciej SiedlarMarek Zembala
Jun 5, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Patrick KleemannRoland Seifert
Aug 19, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Anna MachalińskaBogusław Machaliński
Nov 30, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·E VoulgarisN Pavlidis
Apr 21, 2009·Chemical Reviews·Thomas W MillerDavid D Roberts
Feb 18, 2012·Pediatric Research·Ecaterina SartinaKaren C Young
Feb 7, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Zhaokang ChengDeling Kong
Jun 19, 2009·The New England Journal of Medicine·Jean-Luc Harousseau, Philippe Moreau
Feb 1, 2007·The Journal of Biological Chemistry·James W MurphyElias Lolis
Mar 7, 2007·The Journal of Experimental Medicine·Jessy DeshaneAnupam Agarwal
May 8, 2010·Stem Cells and Development·Mohsin KhanSheikh Riazuddin
Aug 17, 2010·Stem Cells and Development·Xiao Xia ZengGerald Udolph
Dec 6, 2008·Current Opinion in Hematology·Toshinao Kawai, Harry L Malech
Feb 19, 2008·Genes & Development·Dina Arvanitis, Alice Davy
Aug 31, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Dongsheng ZhangYigang Wang
Jun 3, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Janice M LieblerZea Borok
Sep 14, 2011·Molecular Cancer Research : MCR·Randala HamdanEugenie S Kleinerman
Aug 4, 2006·The Journal of Clinical Investigation·Beth Levine, Donald L Sodora
Apr 4, 2007·Blood·Pradeep SathyanarayanaDon M Wojchowski
Jun 11, 2011·Respiratory Research·Annika Andersson-SjölandGunilla Westergren-Thorsson
Nov 8, 2011·Reproductive Biology and Endocrinology : RB&E·Ryan L AshleyThomas R Hansen
Aug 15, 2009·Cell Communication and Signaling : CCS·Thomas SeufferleinGötz von Wichert
Feb 26, 2011·Journal of Translational Medicine·Claudia RubieMartin K Schilling
Apr 30, 2008·Immunome Research·Jane E LattinMatthew J Sweet
Jan 8, 2010·Journal of Cell Science·Amanda P StruckhoffRebecca A Worthylake
Feb 2, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Masafumi Takahashi

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